Low levels of co-receptor CCR5 are sufficient to permit HIV envelope-mediated fusion with resting CD4 T cells

被引：16

作者：

Chanel, C

Staropoli, I

Baleux, F

Amara, A

Valenzuela-Fernandez, A

Virelizier, JL

Arenzana-Seisdedos, F

Altmeyer, R

机构：

[1] Inst Pasteur, Unite Immunol Virale, F-75015 Paris, France

[2] Inst Pasteur, Unite Chim Organ, F-75015 Paris, France

来源：

AIDS | 2002年 / 16卷 / 17期

关键词：

D O I：

10.1097/00002030-200211220-00016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The susceptibility of phenotypically CCR3-negative resting CD4 T cells for membrane fusion with a CCR5-specific HIV-1 envelope was analysed using a novel sensitive fusion assay. A very low overall density of CCR5 on T cells expressing high levels of CD4 was shown to be sufficient for HIV envelope-mediated membrane fusion. These findings are relevant to the understanding of how HIV-1 R5 strains enter and replicate in resting CD4 T cells in vivo.

引用

页码：2337 / 2340

页数：4

共 50 条

[1] HIV envelope-mediated, CCR5/α4β7-dependent killing of CD4-negative γδ T cells which are lost during progression to AIDS
Li, Haishan
Pauza, C. David
BLOOD, 2011, 118 (22) : 5824 - 5831
[2] T cells chronically infected with HIV do not contain sufficient Nef to promote CD4 downmodulation in the absence of envelope-mediated effects
Cucchiarini, M
Barcellini-Couget, S
Lefebvre, JC
Doglio, A
JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES AND HUMAN RETROVIROLOGY, 1998, 17 (02): : 112 - 119
[3] Critical roles for Akt kinase in controlling HIV envelope-mediated depletion of CD4 T cells
Haishan Li
C David Pauza
Retrovirology, 10
[4] Critical roles for Akt kinase in controlling HIV envelope-mediated depletion of CD4 T cells
Li, Haishan
Pauza, C. David
RETROVIROLOGY, 2013, 10
[5] Early intermediates in HIV-1 envelope glycoprotein-mediated fusion triggered by CD4 and co-receptor complexes
Dimitrov, AS
Xiao, XD
Dimitrov, DS
Blumenthal, R
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (32) : 30335 - 30341
[6] The role of the CD4 receptor versus HIV coreceptors in envelope-mediated apoptosis in peripheral blood mononuclear cells
Arthos, J
Cicala, C
Selig, SM
White, AA
Ravindranath, HM
Van Ryk, D
Steenbeke, TD
Machado, E
Khazanie, P
Hanback, MS
Hanback, DB
Rabin, RL
Fauci, AS
VIROLOGY, 2002, 292 (01) : 98 - 106
[7] Fc-Gamma-receptor-mediated trogocytosis of HIV co-receptor CCR5 facilitates HIV infection
Chen, Hong-Ru
Albanese, Manuel
Muenchhoff, Maximilian
Gapp, Madeleine
Hofmann, Katharina
Keppler, Oliver
INFECTION, 2021, 49 (SUPPL 1) : S4 - S4
[8] Downregulation of CCR5 on activated CD4 T cells in HIV-infected Indians
Dubey, Shweta
Khalid, Mohammad
Wesley, Clement
Khan, Samir Ali
Wanchu, Ajay
Jameel, Shahid
JOURNAL OF CLINICAL VIROLOGY, 2008, 43 (01) : 25 - 31
[9] Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV
Tebas, Pablo
Stein, David
Tang, Winson W.
Frank, Ian
Wang, Shelley Q.
Lee, Gary
Spratt, S. Kaye
Surosky, Richard T.
Giedlin, Martin A.
Nichol, Geoff
Holmes, Michael C.
Gregory, Philip D.
Ando, Dale G.
Kalos, Michael
Collman, Ronald G.
Binder-Scholl, Gwendolyn
Plesa, Gabriela
Hwang, Wei-Ting
Levine, Bruce L.
June, Carl H.
NEW ENGLAND JOURNAL OF MEDICINE, 2014, 370 (10): : 901 - 910
[10] Mobility of the human immunodeficiency virus (HIV) receptor CD4 and coreceptor CCR5 in living cells: Implications for HIV fusion and entry events
Steffens, CM
Hope, TJ
JOURNAL OF VIROLOGY, 2004, 78 (17) : 9573 - 9578

← 1 2 3 4 5 →