Effect of microfluidization parameters on the physical properties of PEG-PLGA nanoparticles prepared using high pressure microfluidization
被引:11
|
作者:
Sani, Shabnam N.
论文数: 0引用数: 0
h-index: 0
机构:
Idaho State Univ, Dept Pharmaceut Sci, Pocatello, ID 83209 USA
Coll Pharm & Hlth Sci, Dept Pharmaceut Sci, Boston, MA USAButler Univ, Dept Pharmaceut Sci, Indianapolis, IN 46208 USA
Sani, Shabnam N.
[2
,3
]
Das, Nandita G.
论文数: 0引用数: 0
h-index: 0
机构:
Butler Univ, Dept Pharmaceut Sci, Indianapolis, IN 46208 USAButler Univ, Dept Pharmaceut Sci, Indianapolis, IN 46208 USA
Das, Nandita G.
[1
]
Das, Sudip K.
论文数: 0引用数: 0
h-index: 0
机构:
Butler Univ, Dept Pharmaceut Sci, Indianapolis, IN 46208 USAButler Univ, Dept Pharmaceut Sci, Indianapolis, IN 46208 USA
Das, Sudip K.
[1
]
机构:
[1] Butler Univ, Dept Pharmaceut Sci, Indianapolis, IN 46208 USA
[2] Idaho State Univ, Dept Pharmaceut Sci, Pocatello, ID 83209 USA
[3] Coll Pharm & Hlth Sci, Dept Pharmaceut Sci, Boston, MA USA
The objective of this work was to develop uniformly distributed poly(ethylene glycol) grafted poly(lactide-co-glycolide) (PEG-PLGA) nanoparticles of mean size range similar to 100-200nm using ethyl acetate as the solvent. In the multiple emulsion solvent evaporation method a high pressure microfluidization process was adopted to produce the W/O/W multiple emulsion. Non-toxic ethyl acetate was used to solubilize PEG-PLGA. The mean size of nanoparticles obtained was less than 180 nm. The particle size and size distribution were dependent on the microfluidization conditions applied. Mean particle size steadily increased from 121nm at three passes to 172nm at 20 passes of the microfluidizer, indicating that over-processing may be detrimental to PEG-PLGA nanoparticles prepared using this technique. There was no significant alteration of the PEG-PLGA matrix, as evidenced from the differential scanning calorimetric studies.