Alteration of c-fos gene methylation in human gliomas

被引：0
|
作者：
Uyeno, S
Komura, J
Tawa, R
Aoki, Y
Nata, M
Sasano, H
Nakura, H
Sagisaka, K
Sakurai, H
Kayama, T
Yoshimoto, T
Ono, T
机构：
[1] TOHOKU UNIV,SCH MED,DEPT RADIAT RES,AOBA KU,SENDAI,MIYAGI 98077,JAPAN
[2] TOHOKU UNIV,SCH MED,DEPT NEUROSURG,SENDAI,MIYAGI 980,JAPAN
[3] TOHOKU UNIV,SCH MED,DEPT FORENS MED,SENDAI,MIYAGI 980,JAPAN
[4] TOHOKU UNIV,SCH MED,DEPT PATHOL,SENDAI,MIYAGI 980,JAPAN
[5] KYOTO PHARMACEUT UNIV,DEPT ANALYT CHEM,KYOTO,JAPAN
来源：
MOLECULAR CARCINOGENESIS | 1996年 / 16卷 / 02期
关键词：
human glioma; DNA methylation; proto-oncogene; suppressor oncogene; c-fos;
D O I：
10.1002/(SICI)1098-2744(199606)16:2<91::AID-MC5>3.0.CO;2-Q
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In an attempt to find a common DNA alteration occurring in human glioma, we examined DNA methylation in 34 gliomas of various pathological grades and compared them with those in normal cerebral subcortex DNA. The total methylated cytosine levels in the genome did not differ appreciably between the tumors and the normal tissues; however, the degree of DNA methylation in several proto-oncogenes and suppressor oncogenes showed some alterations. Among them, the c-fos gene demonstrated deviation from that of normal tissues in all cases examined, Suggesting that the alteration of c-fos gene methylation plays a role in the early steps of human glioma development. (C) 1996 Wiley-Liss, Inc.
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收藏
页码：91 / 100
页数：10
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