Cardiovascular Toxicities of Androgen Deprivation Therapy

被引：35

作者：

Challa, Azariyas A. ^{[1
]}

Calaway, Adam Christopher ^{[2
]}

Cullen, Jennifer ^{[3
]}

Garcia, Jorge ^{[4
]}

Desai, Nihar ^{[5
,6
]}

Weintraub, Neal L. ^{[7
,8
]}

Deswal, Anita ^{[9
]}

Kutty, Shelby ^{[10
,11
]}

Vallakati, Ajay ^{[1
]}

Addison, Daniel ^{[1
]}

Baliga, Ragavendra ^{[1
]}

Campbell, Courtney M. ^{[1
]}

Guha, Avirup ^{[1
,12
]}

机构：

[1] Ohio State Univ, Dept Internal Med, Wexner Med Ctr, Cardiooncol Program,Div Cardiovasc Med, Columbus, OH 43210 USA

[2] Case Western Reserve Univ, Sch Med, Dept Urol, Univ Hosp Cleveland Med Ctr, Cleveland, OH USA

[3] Case Comprehens Canc Ctr, Dept Populat & Quantitat Hlth Sci, Cleveland, OH USA

[4] Case Western Reserve Univ, Sch Med, Univ Hosp Seidman Canc Ctr, Div Solid Tumor Oncol, Cleveland, OH USA

[5] Yale Univ, Sch Med, Sect Cardiovasc Med, New Haven, CT USA

[6] Ctr Outcomes Res & Evaluat, New Haven, CT USA

[7] Augusta Univ, Vasc Biol Ctr, August, GA USA

[8] Augusta Univ, Med Coll Georgia, Dept Med, August, GA USA

[9] Univ Texas MD Anderson Canc Ctr, Dept Cardiol, Houston, TX 77030 USA

[10] Johns Hopkins Univ Hosp, Helen B Taussig Heart Ctr, Baltimore, MD 21287 USA

[11] Johns Hopkins Univ, Baltimore, MD USA

[12] UH Cleveland Med Ctr, Harrington Heart & Vasc Inst, Cleveland, OH 44106 USA

来源：

CURRENT TREATMENT OPTIONS IN ONCOLOGY | 2021年 / 22卷 / 06期

关键词：

Prostate cancer; Cardiovascular disease; Mortality; Side effects; Cardiotoxicity; Hormones; Prevention; METASTATIC PROSTATE-CANCER; OPEN-LABEL; SUPPRESSION THERAPY; HORMONE ANTAGONIST; RISK-FACTOR; MEN; TESTOSTERONE; DISEASE; RECEPTOR; METAANALYSIS;

D O I：

10.1007/s11864-021-00846-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Opinion statement Prostate cancer is the second leading cause of cancer death in men, and cardiovascular disease is the number one cause of death in patients with prostate cancer. Androgen deprivation therapy, the cornerstone of prostate cancer treatment, has been associated with adverse cardiovascular events. Emerging data supports decreased cardiovascular risk of gonadotropin releasing hormone (GnRH) antagonists compared to agonists. Ongoing clinical trials are assessing the relative safety of different modalities of androgen deprivation therapy. Racial disparities in cardiovascular outcomes in prostate cancer patients are starting to be explored. An intriguing inquiry connects androgen deprivation therapy with reduced risk of COVID-19 infection susceptibility and severity. Recognition of the cardiotoxicity of androgen deprivation therapy and aggressive risk factor modification are crucial for optimal patient care.

引用

页数：20

共 50 条

[1] Cardiovascular Toxicities of Androgen Deprivation Therapy
Azariyas A. Challa
Adam Christopher Calaway
Jennifer Cullen
Jorge Garcia
Nihar Desai
Neal L. Weintraub
Anita Deswal
Shelby Kutty
Ajay Vallakati
Daniel Addison
Ragavendra Baliga
Courtney M. Campbell
Avirup Guha
Current Treatment Options in Oncology, 2021, 22
[2] Androgen deprivation therapy and cardiovascular disease
Melloni, Chiara
Roe, Matthew T.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, 2020, 38 (02) : 45 - 52
[3] CARDIOVASCULAR DISEASES AND ANDROGEN DEPRIVATION THERAPY
Boban, Marko
ACTA CLINICA CROATICA, 2019, 58 (01) : 60 - 63
[4] Androgen deprivation therapy and cardiovascular complications
Poljak, Z.
Hulin, I
Maruscakova, L.
Carter, A.
Mladosievicova, B.
BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, 2016, 117 (10): : 557 - 561
[5] Cardiovascular Toxicity of Androgen Deprivation Therapy
Julia Boland
William Choi
Maximillian Lee
Jianqing Lin
Current Cardiology Reports, 2021, 23
[6] Cardiovascular Risks of Androgen Deprivation Therapy
Ribeiro, Adriano Freitas
Camara, Cesar
Segre, Carlos Alexandre
Srougi, Miguel
Serrano, Carlos V., Jr.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA, 2010, 95 (03) : 412 - 415
[7] Cardiovascular risk with androgen deprivation therapy
Rosenberg, Matt T.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2020, 74 (03)
[8] Cardiovascular Toxicity of Androgen Deprivation Therapy
Boland, Julia
Choi, William
Lee, Maximillian
Lin, Jianqing
CURRENT CARDIOLOGY REPORTS, 2021, 23 (08)
[9] Androgen Deprivation Therapy and Cardiovascular Risk
Punnen, Sanoj
Cooperberg, Matthew R.
Sadetsky, Natalia
Carroll, Peter R.
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (26) : 3510 - 3516
[10] Cardiovascular risk and androgen deprivation therapy
Mina Razzak
Nature Reviews Urology, 2012, 9 (2) : 61 - 61

← 1 2 3 4 5 →