Asymmetric hydrogenolysis of racemic 3-substitued-3-hydroxy-isoindolin-1-ones employing SPINOL-derived chiral phosphoric acid

被引：12
|
作者：
Zhang, Yiliang [1 ,2 ]
He, Li [1 ,2 ]
Shi, Lei [1 ,2 ]
机构：
[1] Harbin Inst Technol, Shenzhen Grad Sch, Shenzhen 518055, Peoples R China
[2] Harbin Inst Technol, Sch Chem & Chem Engn, MIIT Key Lab Crit Mat Technol New Energy Convers, Harbin 150001, Heilongjiang, Peoples R China
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 16期
关键词：
Asymmetric catalysis; Chiral phosphoric acid; Hydrogenolysis; Hantzsch ester; IONIC HYDROGENATION; BENZYLIC ALCOHOLS; TERTIARY ALCOHOLS; SYNTHETIC METHODS; FORMIC-ACID; ISOINDOLINONES; EFFICIENT; FLUORIDE; TRIETHYLSILANE; PHSCF2SIME3;
D O I：
10.1016/j.tetlet.2018.03.030
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The asymmetric hydrogenolysis of racemic 3-substitued-3-hydroxyisoindolin-1-ones has been developed employing SPINOL-derived phosphoric acid and a high steric demand Hantzsch ester as the hydrogen source. The corresponding products are obtained in good yields and up to 93% enantioselectivities. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1592 / 1595
页数：4
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