Effects of dietary salt load and salt depletion on the course of hypertension and angiotensin II levels in male and female heterozygous Ren-2 transgenic rats

被引:18
|
作者
Huskova, Zuzana
Kramer, Herbert
Vanourkova, Zdenka
Thumova, Monika
Maly, Jan
Opocensky, Martin
Skaroupkova, Petra
Kolsky, Alexander
Vernerova, Zdena
Cervenka, Ludek [1 ]
机构
[1] Charles Univ Prague, Inst Clin & Expt Med, Dept Expt Med, 1958-9 Videnska, CZ-14000 Prague 4, Czech Republic
[2] Charles Univ Prague, Cardiovasc Res Ctr, CZ-14000 Prague 4, Czech Republic
[3] Charles Univ Prague, Dept Pediat, Thomas Teaching Hosp, CZ-14000 Prague 4, Czech Republic
[4] Charles Univ Prague, Fac Med 3, Dept Pathol, CZ-14000 Prague 4, Czech Republic
[5] Charles Univ Prague, Fac Med 2, Dept Physiol, CZ-14000 Prague 4, Czech Republic
[6] Univ Bonn, Dept Med, Nephrol Sect, Med Policlin, D-5300 Bonn, Germany
来源
KIDNEY & BLOOD PRESSURE RESEARCH | 2007年 / 30卷 / 01期
关键词
renin transgenic rats; male; female; sex differences; hypertension; ANG II levels; plasma; kidney; salt diet; normal; high; low;
D O I
10.1159/000099028
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Background: In the present study we evaluated plasma and kidney angiotensin II (ANG II) levels in female and male Ren-2 transgenic rats (TGR) in comparison to age-matched female and male normotensive Hannover Sprague-Dawley rats. Methods: The rats were maintained on a normal sodium (NS) diet (0.6% NaCl) or fed a high sodium (HS) diet (2% NaCl) for 4 days or were sodium depleted by administration of 40 mg furosemide per liter drinking water overnight followed by 3 days of low sodium diet (0.01% NaCl) (LS + F). ANG II levels were determined by radioimmunoassay. Results: Female TGR at the age of 38 days were already hypertensive and had developed cardiac hypertrophy, whereas male TGR at this age still exhibited a normotensive phenotype. HS diet increased the blood pressure (BP) but did not alter the ANG II levels in TGR at any age. LS + F decreased the BP without significant change in ANG II concentrations in TGR. Female TGR responded to salt loading and salt depletion by more pronounced changes in BP than male TGR. Conclusions: Female TGR develop hypertension more rapidly and the salt-sensitive component of hypertension is more pronounced in female than in male TGR. Copyright (c) 2007 S. Karger AG, Basel.
引用
收藏
页码:45 / 55
页数:11
相关论文
共 50 条
  • [21] Effects of sodium restriction and cyclooxygenase-2 inhibition on the course of hypertension, proteinuria and cardiac hypertrophy in Ren-2 transgenic rats
    Vanecková, I
    Skaroupková, P
    Dvorák, P
    Chábová, VC
    Tesar, V
    Bader, M
    Ganten, D
    Kramer, HJ
    PHYSIOLOGICAL RESEARCH, 2005, 54 (01) : 17 - 24
  • [22] PROXIMAL TUBULAR FLUID, KIDNEY AND PLASMA-LEVELS OF ANGIOTENSIN-II IN ANESTHETIZED HYPERTENSIVE REN-2 TRANSGENIC RATS
    MITCHELL, KD
    LEWIS, L
    HYMEL, A
    MULLINS, JJ
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1995, 6 (03): : 627 - 627
  • [23] Chronic endothelin receptor blockade reduces end-organ damage independently of blood pressure effects in salt-loaded heterozygous Ren-2 transgenic rats
    Opocensky, M
    Dvorák, P
    Maly, J
    Kramer, HJ
    Bäcker, A
    Kopkan, L
    Vernerová, Z
    Tesar, V
    Zima, T
    Bader, M
    Ganten, D
    Janda, J
    Vanecková, I
    PHYSIOLOGICAL RESEARCH, 2004, 53 (06) : 581 - 593
  • [24] Modulation of tubuloglomerular feedback by angiotensin II and nitric oxide in hypertensive REN-2 transgenic rats.
    Mitchell, KD
    FASEB JOURNAL, 2000, 14 (04): : A134 - A134
  • [25] Kidney and plasma levels of angiotensin II during reduced renal arterial pressure in hypertensive REN-2 transgenic rats.
    Jacinto, SM
    Schilleci, JT
    Hymel, A
    Mitchell, KD
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1996, 7 (09): : A1426 - A1426
  • [26] Local angiotensin II formation in kidney tissue contributes to nephrosclerosis in Ren-2 transgenic hypertensive rats
    Hartner, A
    Klanke, B
    Schmieder, RE
    Veelken, R
    Hilgers, KF
    HYPERTENSION, 2001, 38 (03) : 495 - 495
  • [27] Plasma and kidney angiotensin II levels and renal functional responses to AT1 receptor blockade in hypertensive Ren-2 transgenic rats
    Kopkan, L
    Kramer, HJ
    Husková, Z
    Vanourková, Z
    Bäcker, A
    Bader, M
    Ganten, D
    Cervenka, L
    JOURNAL OF HYPERTENSION, 2004, 22 (04) : 819 - 825
  • [28] Effects of chronic cytochrome P-450 inhibition on the course of hypertension and end-organ damage in Ren-2 transgenic rats
    Chabova, Vera Certikova
    Kramer, Herbert J.
    Vaneckova, Ivana
    Vernerova, Zdena
    Eis, Vaclav
    Tesar, Vladimir
    Skaroupkova, Petra
    Thumova, Monika
    Schejbalova, Stanislava
    Huskova, Zuzana
    Vanourkova, Zdenka
    Kolsky, Alexander
    Imig, John D.
    Cervenka, Ludek
    VASCULAR PHARMACOLOGY, 2007, 47 (2-3) : 145 - 159
  • [29] BLOOD PRESSURE EFFECTS OF SYSTEMIC OR CENTRAL ANGIOTENSIN II IN HYPERTENSIVE REN-2 TRANSGENIC RATS: SYMPATHOINHIBITION INDUCED BY CENTRAL RAS BLOCKADE
    Zicha, Josef
    Rezacova, Lenka
    Hojna, Silvie
    Vaneckova, Ivana
    JOURNAL OF HYPERTENSION, 2018, 36 : E42 - E42
  • [30] Endogenous angiotensin II and cell hypertrophy in vascular smooth muscle cultures from hypertensive Ren-2 transgenic rats
    Perió, C
    Rodríguez-López, AM
    Angulo, J
    Regadera, J
    Marín, J
    Sánchez-Ferrer, CF
    López-Novoa, JM
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 1998, 8 (1-2) : 106 - 116