Multiple Gene Status in Helicobacter pylori Strains and Risk of Gastric Cancer Development

被引:30
作者
Douraghi, Masoumeh [1 ]
Talebkhan, Yeganeh [1 ]
Zeraati, Hojjat [2 ]
Ebrahimzadeh, Fatemeh [1 ]
Nahvijoo, Azin [3 ]
Morakabati, Arman [4 ]
Ghafarpour, Masoud [1 ]
Esmaili, Maryam [1 ]
Bababeik, Maryam [1 ]
Oghalaie, Akbar [1 ]
Rakhshani, Nasser [5 ]
Hosseini, Mahmoud Eshagh [6 ]
Mohagheghi, Mohammad Ali [3 ]
Mohammadi, Marjan [1 ]
机构
[1] Pasteur Inst Iran, Biotechnol Res Ctr, Helicobacter Pylori Res Grp, Tehran 13164, Iran
[2] Univ Tehran Med Sci, Sch Publ Hlth, Dept Epidemiol & Biostat, Qom, Iran
[3] Univ Tehran Med Sci, Canc Res Ctr, Qom, Iran
[4] Qom Univ Med Sci, Sch Med, Qom, Iran
[5] Iran Univ Med Sci, Gastrointestinal & Liver Dis Res Ctr, Tehran, Iran
[6] Univ Tehran Med Sci, Amiralam Hosp, Endoscopy Unit, Tehran, Iran
关键词
vacA intermediate region; cagA; Anti-VacA; Dysplasia; Intestinal metaplasia; Gastric cancer; VACUOLATING CYTOTOXIN ALLELES; VACA; CAGA; HOST; ANTIBODIES; DIVERSITY; REGION; SYSTEM;
D O I
10.1159/000229774
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background/Aim: The identification of the vacA intermediate region has provided new insights into the role of vacA heterogeneity in relation to gastro-duodenal pathogenesis. The aim of this study was to assess vacA polymorphism in Iranian Helicobacter pylori strains and its association with cagA as a major virulence determinant, gastric histopathology and disease. Methods: vacA polymorphism and serum antibody responses were studied in 207 H. pylori-infected (139 NUD, 34 PUD, and 34 GC) patients and correlated with gastric histopathology. Results: Multivariate logistic regression analysis found intermediate region typing superior to signal or mid region typing for screening high risk patients. vacA i1 allele was identified as an independent predictor of dysplasia (OR = 9.044; 95% CI: 1.11-73.33). Possession of s1/i1/cagA(+) strains was also identified as a predictor of intestinal metaplasia (OR = 3; 95% CI: 1.13-7.95), dysplasia (OR = 9.9; 95% CI: 1.23-80.86) and risk of GC (OR = 6.9; 95% CI: 2.5-18.66) as well as induction of anti-VacA sero-positivity (OR = 5.04; 95% CI: 1.8-13.6). Anti-VacA serology correctly detected 83.8% of s1/i1/cagA(+) strains carried by high-risk patients. Conclusions: The current study emphasizes the implication of vacA polymorphic structure, especially the s1/i1/cagA(+) genotype, in increasing the risk of GC by revealing their association with gastric pre-neoplastic changes and their reflection in VacA sero-positivity which encourages the application of noninvasive procedures in population screening. Copyright (C) 2009 S. Karger AG, Basel
引用
收藏
页码:200 / 207
页数:8
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