Evaluation of immunotherapy (I-O)-associated immune cell (IC) dynamics and PD-L1 expression using multispectral immunohistochemistry (mIHC) and single-cell hierarchical regression modeling in early-stage breast cancer (ESBC).

被引:0
|
作者
Sanchez, Katherine
Martel, Maritza
Chang, Shu-Ching
Wu, Yaping
Sun, Zhaoyu
Nyberg, Richard
Redmond, William L.
Pucilowska, Joanna
Aliabadi-Wahle, Shaghayegh
Imatani, James
Conlin, Alison Katherine
Bernard, Brady
Shah, Monil
Wadell, Dottie
Laxaque, Deborah R.
Wen, Lu
Li, Qiao
Wolf, Gregory T.
Urba, Walter John
Page, David B.
机构
[1] Robert W Franz Canc Ctr, Earle A Chiles Res Inst, Portland, OR USA
[2] Med Data Res Ctr, Portland, OR USA
[3] Brooklyn ImmunoTherapeut, New York, NY USA
[4] Univ Michigan, Rogel Canc Ctr, Ann Arbor, MI 48109 USA
关键词
D O I
10.1200/JCO.2019.37.15_suppl.e12070
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
e12070
引用
收藏
页数:2
相关论文
共 6 条
  • [1] Multispectral immunofluorescence (mIF) to detect dynamic changes in PD-L1 expression, immune cell (IC) infiltration, and tumor-IC interactions in primary breast cancer (BC) immuno-oncology (I-O) clinical trials
    Sanchez, Katherine
    Kim, Isaac
    Chang, ShuChing
    Martel, Maritza
    Wu, Yaping
    Bernard, Brady
    Pucilowska, Joanna
    Sun, Zhaoyu
    Redmond, William
    Waddell, Dottie
    Urba, Walter
    Page, David B.
    CANCER RESEARCH, 2020, 80 (04)
  • [2] Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer
    Zhang, Yuanyuan
    Chen, Hongyan
    Mo, Hongnan
    Hu, Xueda
    Gao, Ranran
    Zhao, Yahui
    Liu, Baolin
    Niu, Lijuan
    Sun, Xiaoying
    Yu, Xiao
    Wang, Yong
    Chang, Qing
    Gong, Tongyang
    Guan, Xiuwen
    Hu, Ting
    Qian, Tianyi
    Xu, Binghe
    Ma, Fei
    Zhang, Zemin
    Liu, Zhihua
    CANCER CELL, 2021, 39 (12) : 1578 - +
  • [3] Clinical factors associated with high PD-L1 expression in patients with early-stage non-small cell lung cancer
    Ohara, Shuta
    Suda, Kenichi
    Hamada, Akira
    Chiba, Masato
    Ito, Masaoki
    Shimoji, Masaki
    Takemoto, Toshiki
    Soh, Junichi
    Tsutani, Yasuhiro
    THORACIC CANCER, 2024, 15 (31) : 2229 - 2234
  • [4] Landscape of Genomic Alterations and PD-L1 Expression in Early-Stage Non-Small-Cell Lung Cancer (NSCLC)-A Single Center, Retrospective Observational Study
    Stephan-Falkenau, Susann
    Streubel, Anna
    Mairinger, Thomas
    Kollmeier, Jens
    Misch, Daniel
    Thiel, Sebastian
    Bauer, Torsten
    Pfannschmidt, Joachim
    Hollmann, Manuel
    Wessolly, Michael
    Blum, Torsten Gerriet
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (20)
  • [5] EGFR Mutations and PD-L1 Expression in Early-Stage Non-Small Cell Lung Cancer: A Real-World Data From a Single Center in Brazil
    Pinto, Icaro Alves
    Cavagna, Rodrigo de Oliveira
    Virginio da Silva, Aline Larissa
    Dias, Josiane Mourao
    Santana, Iara Vidigal
    Souza, Laisa Caroline
    Ferreira da Silva, Flavio Augusto
    Biazotto Fernandes, Maria Fernanda
    Junqueira Pinto, Gustavo Dix
    Negreiros, Izabella Santos
    Santiago Goncalves, Maria Fernanda
    de Paula, Flavia Escremim
    Berardinelli, Gustavo Noriz
    Stanfoca Casagrande, Giovanna Maria
    da Silva, Marcela Oliveira
    Albino da Silva, Eduardo Caetano
    de Oliveira, Marco Antonio
    Jacinto, Alexandre Arthur
    da Silva, Vinicius Duval
    Reis, Rui Manuel
    De Marchi, Pedro
    Leal, Leticia Ferro
    ONCOLOGIST, 2022, 27 (11): : E899 - E907
  • [6] PD-L1 expression and Tumor mutation burden as Pathological response biomarkers of Neoadjuvant immunotherapy for Early-stage Non-small cell lung cancer: A systematic review and meta-analysis
    Deng, Hongsheng
    Zhao, Yi
    Cai, Xiuyu
    Chen, Hualin
    Cheng, Bo
    Zhong, Ran
    Li, Feng
    Xiong, Shan
    Li, Jianfu
    Liu, Jun
    He, Jianxing
    Liang, Wenhua
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2022, 170