Synthesis of Enantiopure Benzo Fused Cyclic Sulfoximines Through Stereoselective [3+2] Cycloaddition between N-tert-Butanesulfinyl [(2-Pyridyl)sulfonyl]-difluoromethyl Ketimines and Arynes

被引：6
|
作者：
Rong, Jian [1 ]
Ni, Chuanfa [1 ]
Gu, Yucheng [2 ]
Hu, Jinbo [1 ]
机构：
[1] Univ Chinese Acad Sci, Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem,Ctr Excellence Mol Sy, 345 Ling Ling Rd, Shanghai 200032, Peoples R China
[2] Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England
来源：
HELVETICA CHIMICA ACTA | 2021年 / 104卷 / 04期
基金：
中国国家自然科学基金;
关键词：
arynes; cycloaddition; fluorine; N-tert-butanesulfinyl imine; sulfoximines;
D O I：
10.1002/hlca.202100019
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The previously developed stereoselective [3+2] cycloaddition between N-tert-butanesulfinyl ketimines and arynes has been extended to the synthesis of enantiopure [(2-pyridyl)sulfonyl]difluoromethylated cyclic sulfoximines. The use of 2-PySO2CF2 as the facilitating group offers new opportunities for the elaboration of the [3+2] cycloaddition products by virtue of the diverse relativity of 2-pyridyl sulfones.
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页数：7
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