18F-FDG PET/CT Cannot Substitute Endoscopy in the Staging of Gastrointestinal Involvement in Mantle Cell Lymphoma. A Retrospective Multi-Center Cohort Analysis

被引：2

作者：

Skrypets, Tetiana ^{[1
]}

Ferrari, Cristina ^{[2
]}

Nassi, Luca ^{[3
]}

Casaluci, Gloria Margiotta ^{[3
]}

Puccini, Benedetta ^{[4
]}

Mannelli, Lara ^{[4
]}

Filonenko, Kateryna ^{[5
]}

Kryachok, Irina ^{[5
]}

Clemente, Felice ^{[1
]}

Vegliante, Maria Carmela ^{[1
]}

Daniele, Antonella ^{[6
]}

Sacchetti, Gianmauro ^{[7
]}

Guarini, Attilio ^{[1
]}

Minoia, Carla ^{[1
]}

机构：

[1] IRCCS Ist Tumori Giovanni Paolo II, Haematol Unit, I-70124 Bari, Italy

[2] Univ Bari Aldo Moro, DIM Diagnost Imaging Nucl Med, I-70124 Bari, Italy

[3] Azienda Osped Univ Maggiore Carita, Haematol Dept, I-28100 Novara, Italy

[4] Azienda Osped Careggi, Hematol Dept, I-50139 Florence, Italy

[5] Natl Canc Inst, Oncohematol Dept, UA-03022 Kiev, Ukraine

[6] IRCCS Ist Tumori Giovanni Paolo II, Expt Oncol & Biobank Management Unit, I-70124 Bari, Italy

[7] AOU Maggiore Carita, Nucl Med, I-28100 Novara, Italy

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2021年 / 11卷 / 02期

关键词：

Mantle Cell Lymphoma; staging; endoscopy; gastric biopsy; colorectal biopsy; 18F-FDG PET/CT;

D O I：

10.3390/jpm11020123

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

The detection of gastrointestinal (GI) involvement in Mantle Cell Lymphoma is often underestimated and may have an impact on outcome and clinical management. We aimed to evaluate whether baseline 18F-FDG PET/CT presents comparable results to endoscopic biopsy in the diagnosis of GI localizations. In our retrospective cohort of 79 patients, sensitivity and specificity of 18F-FDG PET/CT were low for the stomach, with a fair concordance (k = 0.32), while higher concordance with pathologic results (k = 0.65) was detected in the colorectal tract. Thus, gastric biopsy remains helpful in the staging of MCL despite 18F-FDG PET/CT, while colonoscopy could be omitted in asymptomatic patients. The validation of our data in prospective cohorts is desirable

引用

页码：1 / 10

页数：9

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