Studies on the formation of a complex of Cu(II) with sodium 1,4-dihydroxy-9,10-anthraquinone-2-sulphonate - An analogue of the core unit of anthracycline anticancer drugs and its interaction with calf thymus DNA

被引：61
|
作者：
Guin, Partha Sarathi [1 ,2 ]
Das, Saurabh [2 ]
Mandal, P. C. [1 ]
机构：
[1] Saha Inst Nucl Phys, Div Chem Sci, Kolkata 700064, India
[2] Jadavpur Univ, Dept Chem, Kolkata 700032, India
来源：
JOURNAL OF INORGANIC BIOCHEMISTRY | 2009年 / 103卷 / 12期
关键词：
Cu(II); NaQSH(2); Stoichiometry; Stability constant; SEM; MS; Cyclic voltammetry; Calf thymus DNA; Binding parameters; TRANSITION-METAL-COMPLEXES; AQUEOUS-SOLUTION; PHYSICOCHEMICAL CHARACTERISTICS; COPPER(II) ADRIAMYCIN; CHELATE POLYMERS; MIXED-SOLVENT; STEADY-STATE; BINDING; 1,2-DIHYDROXY-9,10-ANTHRAQUINONE; DERIVATIVES;
D O I：
10.1016/j.jinorgbio.2009.09.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Copper(II) forms a complex with sodium 1,4-dihydroxy-9,10-anthraquinone-2-sulphonate (sodium quinizarin-2-sulphonate, NaQSH(2)), an analogue of the core unit of anthracycline antibiotics used in the treatment of cancer. The 1:2 metal-ligand complex is formed in aqueous solution at neutral and acidic pH while in alkaline pH both 1: 1 and 1:2 species are formed. The effective stability constant of the 1:2 metal-ligand complex is 9.64 x 10(16) while that of the 1:1 metal-ligand complex is 9.4 x 10(9). The 1:2 complex Cu(NaQSH)(2)(H2O)(2) was synthesized and characterized by different techniques in solid state and in solution. The complex Cu(NaQSH)(2)(H2O)(2) interacts with calf thymus DNA which was studied by fluorescence spectroscopy. The binding constant and site size for the interaction with DNA were determined. (C) 2009 Elsevier Inc. All rights reserved.
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页码：1702 / 1710
页数：9
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