A facile and convenient synthesis of novel imidazo[1,2-b] isoxazoles and their Mannich bases as potential biodynamic agents

被引：6
|
作者：
Rajanarendar, E. [1 ]
Thirupathaiah, K. [1 ]
Ramakrishna, S. [1 ]
Nagaraju, D. [1 ]
机构：
[1] Kakatiya Univ, Dept Chem, Warangal 506009, TS, India
来源：
CHINESE CHEMICAL LETTERS | 2015年 / 26卷 / 12期
关键词：
Imidazo[1,2-b]isoxazoles; 2-Amines; Mannich bases; IN-VITRO; BINDING;
D O I：
10.1016/j.cclet.2015.07.024
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of novel imidazo[1,2-b]isoxazoles 3 and their Mannich bases 4-6 were synthesized via convenient reactions. The reaction of 3-aminoisoxazole 1 with substituted phenacyl bromides 2 in dry ethanol afforded the corresponding 6-methyl-3-aryl imidazo[1,2-b]isoxazoles 3 in good yields. Compounds 3 on treatment with 37% formaline and secondary amines furnished the corresponding novel Mannich bases viz., 6-methyl-3-aryl-2-(morpholine/pyrrolidin-1-yl/piperidin-1-yl)-methyl-imidazo[1,2-b]isoxazoles 4-6. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：1511 / 1513
页数：3
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