Gene amplification and its application in cell and tissue engineering

被引：54
|
作者：
Omasa, T [1 ]
机构：
[1] Osaka Univ, Grad Sch Engn, Dept Biotechnol, Suita, Osaka 5650871, Japan
来源：
JOURNAL OF BIOSCIENCE AND BIOENGINEERING | 2002年 / 94卷 / 06期
关键词：
gene amplification; Chinese hamster ovary (CHO); cell and tissue engineering;
D O I：
10.1016/S1389-1723(02)80201-8
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Gene amplification means the repeated replication of a certain gene without a proportional increase in the copy number of other genes and is a widespread phenomenon in eukaryotes. It is an important developmental and evolutionary process in many organisms. This article focuses on mammalian gene amplification and its application in cell and tissue engineering. The dhfr gene amplification in Chinese hamster ovary (CHO) cells, the gene amplification mechanisra, the selection protocol and the application of gene amplification were reviewed.
引用
收藏
页码：600 / 605
页数：6
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