Twenty-five year mortality of a community cohort with schizophrenia

被引:460
作者
Brown, Steve [1 ]
Kim, Miranda [2 ]
Mitchell, Clemence [3 ]
Inskip, Hazel [2 ]
机构
[1] Hampshire Partnership NHS Trust, Southampton, Hants, England
[2] Univ Southampton, MRC Epidemiol Resource Ctr, Southampton SO9 5NH, Hants, England
[3] Univ Southampton, Sch Med, Southampton SO9 5NH, Hants, England
基金
英国医学研究理事会;
关键词
EXCESS MORTALITY; PSYCHIATRIC-PATIENTS; RISK; DISORDER; DENMARK; PEOPLE; DEATH; TIME;
D O I
10.1192/bjp.bp.109.067512
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background People with schizophrenia have significantly raised mortality but we do not know how these mortality patterns in the UK have changed since the 1990s. Aims To measure the 25-year mortality of people with schizophrenia with particular focus on changes over time Method Prospective record linkage study of the mortality of a community cohort of 370 people with schizophrenia. Results The cohort had an all-cause standardised mortality ratio of 289 (95% CI 247-337). Most deaths were from the common causes seen in the general population. Unnatural deaths were concentrated in the first 5 years of follow-up. There was an indication that cardiovascular mortality may have increased relative to the general population (P=0.053) over the course of the study. Conclusions People with schizophrenia have a mortality risk that is two to three times that of the general population. most of the extra deaths are from natural causes. The apparent increase in cardiovascular mortality relative to the general population should be of concern to anyone with an interest in mental health.
引用
收藏
页码:116 / 121
页数:6
相关论文
共 29 条
[1]  
[Anonymous], 1978, INT STAT CLASS DIS R
[2]  
Breslow N. E., 1987, STAT METHODS CANC RE, V2
[3]   Causes of the excess mortality of schizophrenia [J].
Brown, S ;
Inskip, H ;
Barraclough, B .
BRITISH JOURNAL OF PSYCHIATRY, 2000, 177 :212-217
[4]   The unhealthy lifestyle of people with schizophrenia [J].
Brown, S ;
Birtwistle, J ;
Roe, L ;
Thompson, C .
PSYCHOLOGICAL MEDICINE, 1999, 29 (03) :697-701
[5]   Excess mortality of schizophrenia - A meta-analysis [J].
Brown, S .
BRITISH JOURNAL OF PSYCHIATRY, 1997, 171 :502-508
[6]  
Campion J., 2008, ADV PSYCHIAT TREATME, V14, P208
[7]   Contribution of modern cardiovascular treatment and risk factor changes to the decline in coronary heart disease mortality in Scotland between 1975 and 1994 [J].
Capewell, S ;
Morrison, CE ;
McMurray, JJ .
HEART, 1999, 81 (04) :380-386
[8]  
GARDNER MJ, 1989, BMJ
[9]   SCHIZOPHRENIC-PATIENTS AND THEIR FAMILIES - A SURVEY IN A PSYCHIATRIC-SERVICE BASED ON A DGH UNIT [J].
GIBBONS, JS ;
HORN, SH ;
POWELL, JM ;
GIBBONS, JL .
BRITISH JOURNAL OF PSYCHIATRY, 1984, 144 (JAN) :70-77
[10]   Cause-specific mortality in psychiatric patients after deinstitutionalisation [J].
Hansen, V ;
Jacobsen, BK ;
Arnesen, E .
BRITISH JOURNAL OF PSYCHIATRY, 2001, 179 :438-443