Microbial transformation of isocoronarin D by Cunninghamella echinulata NRRL 1386

被引：5

作者：

Chokchaisiri, Ratchanaporn ^{[1
]}

Chaichompoo, Waraluck ^{[2
,3
]}

Sukcharoen, Oratai ^{[4
]}

Suksamrarn, Apichart ^{[2
,3
]}

Ganranoo, Lucksagoon ^{[1
]}

机构：

[1] Univ Phayao, Sch Sci, Dept Chem, Muang 56000, Phayao, Thailand

[2] Ramkhamhang Univ, Fac Sci, Dept Chem, Bangkok, Thailand

[3] Ramkhamhang Univ, Fac Sci, Ctr Excellence Innovat Chem, Bangkok, Thailand

[4] Ramkhamhang Univ, Fac Sci, Dept Biotechnol, Bangkok, Thailand

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 20期

关键词：

Isocoronarin D; Curcuma comosa; Cunninghamella echinulata; microbial transformation; LABDANE DITERPENES; DRUG-METABOLISM; BIOTRANSFORMATION; BLAKESLEEANA; HYDROXYLATION; FUNGUS; ACID;

D O I：

10.1080/14786419.2018.1509331

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The diterpene isocoronarin D (1) is a bioactive major constituent of labdane diterpene from the aerial parts of Curcuma comosa Roxb. (Zingiberaceae), the Thai medicinal plant. Microbial transformation of 1 was performed by the fungus Cunninghamella echinulata NRRL 1386 to yield three new metabolites, 3 beta-hydroxyisocoronarin D (2), 6 alpha-hydroxyisocoronarin D (3) and 3 beta,7 alpha-dihydroxyisocoronarin D (4). The structures of the new compounds were elucidated by spectroscopic techniques.

引用

页码：2890 / 2896

页数：7

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