Plasma angiotensin II levels in women with severe preeclampsia under magnesium sulfate regimen

被引：1
|
作者：
de Lima, Amanda S. D. [1 ]
Holanda, Ingrid P. [2 ]
Nascimento, Paulo R. P. [3 ]
Jeronimo, Selma M. B. [2 ,3 ,4 ]
Ferreira, Leonardo C. [2 ,3 ]
机构：
[1] Univ Fed Rio Grande do Norte, Maternidade Escola Januario Cicco, Natal, RN, Brazil
[2] Univ Fed Rio Grande do Norte, Dept Biochem, Natal, RN, Brazil
[3] Univ Fed Rio Grande do Norte, Inst Trop Med, Natal, RN, Brazil
[4] Natl Inst Sci & Technol Trop Dis, Salvador, BA, Brazil
来源：
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH | 2021年 / 23卷
关键词：
Preeclampsia; Magnesium; Angiotensin; Seizure;
D O I：
10.1016/j.preghy.2020.11.003
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
The role of Renin-Angiotensin-System (RAS) in the pathogenesis of preeclampsia and eclampsia is still unclear. Our aim was to investigate plasma angiotensin II concentration [Ang II] in women with normotensive pregnancies (NP, n = 22) and severe preeclampsia in use of magnesium sulfate (SPE, n = 29). Despite no difference between the groups (SPE: 47.8 pg/ml vs NP: 39.7 pg/ml, p = 0.195), lower maternal age (p = 0.007) and primigravida (p = 0.028) were associated with lower [Ang III]. Plasma [Ang II] increased over the 24 h of magnesium sulfate administration (r = 0.48, p = 0.009). Our findings suggest that RAS may be involved with the mechanism of magnesium protection against eclamptic seizure.
引用
收藏
页码：56 / 58
页数：3
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