Two new efficient preparations of enantiopure 2,2'-dihydroxy-6,6'-dimethoxy-1,1'-biphenyl

被引：20
|
作者：
Delogu, G
Fabbri, D
机构：
[1] C.N.R, Ist. Per l'Applic. Delle Tecniche C., Via Vienna 2
来源：
TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 05期
关键词：
D O I：
10.1016/S0957-4166(97)00021-9
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Two new useful methods for the preparation of diol 1 starting from available compounds are described. Separation of the two enantiomers entails resolution of racemic diol 1 via the corresponding diastereomeric N-methylated phosphorothioamidates. Their separation by recrystallization followed by reduction afforded diol (aS)-1 and (aR)-1 in 100% and 72% ee, respectively. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码：759 / 763
页数：5
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