Novel stereoselective synthesis of 7β-methyl-substituted 5-androstene derivatives

被引：21

作者：

Zheng, YH ^{[1
]}

Li, YC ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Mat Med, Shanghai 200031, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 04期

关键词：

D O I：

10.1021/jo020290x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The 7beta-methyl-5-androstene derivatives 11a-c were prepared in good yield with high stereoselectivities starting from 3beta-acetoxyandrost-5-en-17-one 4. The addition of methylmagnesium iodide to the 7-carbonyl group of 7a-c gave, after hydrolysis, two isomers 9a-c and 10a-c, which were stereoselectively deoxygenated by means of an ionic hydrogenation to afford the compounds 11a-c.

引用

页码：1603 / 1606

页数：4

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