Glutathione S-transferases and cancer (Review)

被引：0
|
作者：
Schipper, DL
Wagenmans, MJH
Wagener, DJT
Peters, WHM
机构：
[1] UNIV NIJMEGEN HOSP,DEPT GASTROENTEROL,NL-6500 HB NIJMEGEN,NETHERLANDS
[2] UNIV NIJMEGEN HOSP,DEPT MED ONCOL,NL-6500 HB NIJMEGEN,NETHERLANDS
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 1997年 / 10卷 / 06期
关键词：
glutathione S-transferases (GSTs); toxins; carcinogens; anticancer drugs; MALIGNANT OVARIAN-TUMORS; PI-CLASS ISOENZYMES; DRUG-RESISTANCE; BREAST-CANCER; HUMAN-TISSUES; CHEMICAL HEPATOCARCINOGENESIS; CONFERS RESISTANCE; ALPHA-CLASS; GST-PI; EXPRESSION;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cytosolic glutathione S-transferases are a family of enzymes involved in the metabolism of drugs, toxins, carcinogens and also of anticancer drugs. Recent studies have indicated that glutathione S-transferases (GSTs) may play an important role in the resistance of cells to toxins and carcinogens but also to anticancer drugs. This report reviews the current literature concerning the role of glutathione S-transferases in anticancer drug resistance. Moreover, the significance of GST pi in carcinogenesis and its role as prognostic factor is discussed.
引用
收藏
页码：1261 / 1264
页数：4
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