IKB kinase B(IKKB), but not NF-KB-inducing kinase (NIK) or IKKA, represents a therapeutic target for modulation of FAS, IL-1B and TNFA-mediated NF-KB activation in intestinal epithelial cells (IEC).

被引：3

作者：

Russo, MP

Brandham, CA

Bennett, BL

Manning, AM

Brenner, DA

Jobin, C

机构：

[1] Univ N Carolina, Chapel Hill, NC USA

[2] Signal Pharmaceut, San Diego, CA USA

来源：

GASTROENTEROLOGY | 2000年 / 118卷 / 04期

关键词：

D O I：

10.1016/S0016-5085(00)84486-8

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

3048

引用

页码：A587 / A587

页数：1

共 10 条

[1] Adenoviral (Ad5) delivery of wild type IKB kinase B(IKKB) but not Ad5IKKA restored the defective IKB/NF-KB signaling pathway in HT-29 cells.
Schwabe, RF
Russo, MP
Bennett, BL
Manning, AM
Brenner, DA
Sartour, RB
Jobin, C
GASTROENTEROLOGY, 2000, 118 (04) : A614 - A614
[2] Curcumin, a dietary product, blocks cytokine mediated NF-κB activation and proinflammatory gene expression in intestinal epithelial cells by inhibiting IKK activity without directly affecting NF-κB-inducing kinase (NIK) or IGκB kinase (IKK)
Jobin, C
Bradham, CA
Narula, AS
Brenner, DA
Sartor, RB
GASTROENTEROLOGY, 1999, 116 (04) : A743 - A743
[3] Pneumocystis carinii B-glucan-induced chemokine secretion from alveolar epithelial cells requires activation of protein kinase C and NF-KB
Evans, SE
Hahn, PY
Lebron-Ruiz, FM
Kottom, TJ
Puri, V
Pagano, RE
Limper, AH
CHEST, 2003, 124 (04) : 188S - 188S
[4] Differential requirement for transforming growth factor β-activated kinase 1 (TAK1) and protein kinase B (AKT) in LPS, IL-1β and TNF-mediated NF-κB activation in intestinal epithelial cells (IEC).
Russo, MP
Sartor, RB
Jobin, C
GASTROENTEROLOGY, 2001, 120 (05) : A181 - A182
[5] NF-κB-inducing kinase is a common mediator of IL-17-, TNF-α-, and IL-1β-induced chemokine promoter activation in intestinal epithelial cells
Awane, M
Andres, PG
Li, DJ
Reinecker, HC
JOURNAL OF IMMUNOLOGY, 1999, 162 (09): : 5337 - 5344
[6] Bifidobacterium bifidum prevents the IL-1B induced increase in intestinal permeability by a novel mechanism: TLR-2 dependent activation of PPAR-gamma and inhibition of NF-kB signaling pathway
Abdulqadir, Raz
Al-Sadi, Rana
Ma, Thomas
PHYSIOLOGY, 2023, 38
[7] S-Gal-Elastin receptor triggering by matrix-derived peptides induces a potential up-regulation loop through IL-1b expression and NF-kB activation in melanoma cells
Derbet, R
Le Naour, R
Hornebeck, W
Guenounou, M
Bernard, P
Antonicelli, F
FEBS JOURNAL, 2005, 272 : 474 - 475
[8] Over-expression of an IL-1B inhibitor inhibited activation of NF-kB and reduced induction of iNOS precede lipopolysaccharide (LPS)-mediated liver damage in LPS-sensitive ob/ob mice.
Lin, HZ
Yang, SQ
Diehl, AM
HEPATOLOGY, 2000, 32 (04) : 304A - 304A
[9] Tgf-B1-activated SMAD signaling inhibits non-pathogenic gram negative bacteria-induced Nf-Kb recruitment to the II-6 gene promoter through modulation of histone acetylation in intestinal epithelial cells
Haller, D
Holt, L
Kim, SC
Schwabe, RF
Sartor, RB
Jobin, C
GASTROENTEROLOGY, 2003, 124 (04) : A44 - A44
[10] Activation of NF-κB by nontypeable Hemophilus influenzae is mediated by toll-like receptor 2-TAK1-dependent NIK-IKKα/β-IκBα and MKK3/6-p38 MAP kinase signaling pathways in epithelial cells
Shuto, T
Xu, HD
Wang, BN
Han, JH
Kai, HF
Gu, XX
Murphy, TF
Lim, DJ
Li, JD
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (15) : 8774 - 8779

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