PWV;
wave propagation;
fluid-solid interaction;
Moens-Korteweg equation;
large artery;
D O I:
10.1142/9781860948800_0098
中图分类号:
Q6 [生物物理学];
学科分类号:
071011 ;
摘要:
Pulse Wave Velocity (PWV) is recognized by clinicians as an index of mechanical properties of human blood vessels. This concept is based on the Moens-Korteweg equation, which describes the PWV in ideal elastic tubes. However, measured PWV of real human blood vessels cannot be always interpreted by the Moens-Korteweg equation because this formula is not precisely applicable to blood vessels. It is important to understand the wave propagation in blood vessels for a more reliable diagnosis of vascular disease. In this study, we modeled uniform arteries in a three-dimensional coupled fluid-solid interaction computational scheme, and analyzed the pulse wave propagation. A commercial code (Radioss, MECALOG, France) was used to solve the fluid-solid interactions. The governing equations are the compressive Navier-Stokes equations and the equation of continuity for the fluid region, and the equation of equilibrium for the solid region. At the inlet, a steady flow with Reynolds number 1000 was imposed as the basic flow, then a single rectangular pulse with Reynolds number 4000 was imposed upon the basic flow to produce a propagating wave. We compared the PWV values in the uniform artery obtained by computation with those from the Moens-Korteweg equation, and showed the availability of applying the computational technique to wave propagation analysis in human large arteries.