NF-κB regulation in the immune system

被引：3413
|
作者：
Li, QT [1 ]
Verma, IM [1 ]
机构：
[1] Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2002年 / 2卷 / 10期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nri910
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The nuclear factor-kappaB (NF-kappaB)/REL family of transcription factors has a central role in coordinating the expression of a wide variety of genes that control immune responses. There has been intense scientific activity in the NF-kappaB field owing to the involvement of these factors in the activation and regulation of key molecules that are associated with diseases ranging from inflammation to cancer. In this review, we focus on our current understanding of NF-kappaB regulation and its role in the immune system and inflammatory diseases. We also discuss the role of NF-kappaB proteins as potential therapeutic targets in clinical applications.
引用
收藏
页码：725 / 734
页数：10
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