Piglet immunization with a spike subunit vaccine enhances disease by porcine epidemic diarrhea virus

被引：25

作者：

Yu, Jieshi ^{[1
]}

Sreenivasan, Chithra ^{[1
]}

Uprety, Tirth ^{[1
]}

Gao, Rongyuan ^{[2
]}

Huang, Chen ^{[1
]}

Lee, Ella J. ^{[2
]}

Lawson, Steven ^{[3
]}

Nelson, Julie ^{[3
]}

Christopher-Hennings, Jane ^{[3
]}

Kaushik, Radhey S. ^{[2
]}

Nelson, Eric ^{[3
]}

Diel, Diego G. ^{[4
]}

Hause, Ben M. ^{[3
]}

Li, Feng ^{[1
]}

Wang, Dan ^{[1
]}

机构：

[1] Univ Kentucky, Dept Vet Sci, Maxwell H Gluck Equine Res Ctr, Lexington, KY 40506 USA

[2] South Dakota State Univ, Dept Biol & Microbiol, Brookings, SD 57007 USA

[3] South Dakota State Univ, Dept Vet & Biomed Sci, Anim Dis Res & Diagnost Lab, Brookings, SD 57007 USA

[4] Cornell Univ, Coll Vet Med, Dept Populat Med & Diagnost Sci, Anim Hlth Diagnost Ctr, Ithaca, NY 14853 USA

来源：

NPJ VACCINES | 2021年 / 6卷 / 01期

关键词：

D O I：

10.1038/s41541-021-00283-x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunization with an insect cell lysate/baculovirus mixture containing recombinant porcine epidemic diarrhea virus (PEDV) spike protein induced high levels of neutralizing antibodies in both mice and piglets. However, immunization of piglets with this vaccine resulted in enhancement of disease symptoms and virus replication in vaccine recipients exposed to PEDV challenge. Thus, these observations demonstrate a previously unrecognized challenge of PEDV vaccine research, which has important implications for coronavirus vaccine development.

引用

页数：5

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