Propargylic amines constructed via copper-catalyzed three-component coupling of terminal alkynes, benzal halides and amines

被引：27
|
作者：
Lin, Zhewang [1 ]
Yu, Dingyi [1 ]
Zhang, Yugen [1 ]
机构：
[1] Inst Bioengn & Nanotechnol, Singapore 138669, Singapore
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 38期
关键词：
Alternative propargylic amine synthesis; Copper-catalyzed; AHA coupling; ONE-POT SYNTHESIS; ALDEHYDE;
D O I：
10.1016/j.tetlet.2011.07.099
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method for the synthesis of propargylic amines has been developed via an efficient copper(I)-catalyzed three-component coupling reaction of alkynes, benzal halides and amines through C-H and C-halogen activation. This reaction is conducted under mild conditions and provides an alternative method for the synthesis of propargylic amines. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4967 / 4970
页数：4
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