A chiral cobalt(II) complex catalyzed asymmetric formal [3+2] cycloaddition for the synthesis of 1,2,4-triazolines

被引：11
|
作者：
Ma, Baiwei [1 ]
Luo, Weiwei [1 ]
Lin, Lili [1 ]
Liu, Xiaohua [1 ]
Feng, Xiaoming [1 ]
机构：
[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 29期
基金：
中国国家自然科学基金;
关键词：
DIELS-ALDER REACTION; ENANTIOSELECTIVE SYNTHESIS; DIETHYL AZODICARBOXYLATE; 5-ALKOXYOXAZOLES; ALDEHYDES; OXAZOLES; 4-PHENYL-3H-1,2,4-TRIAZOLE-3,5(4H)-DIONE; AMINATION; LIGANDS; ESTERS;
D O I：
10.1039/c7cc01278k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly efficient catalytic asymmetric formal [3+2] cycloaddition reaction of 5-alkoxyoxazoles with azodicarboxylate compounds has been realized by a chiral N, N'-dioxide/Co(BF4)(2)center dot 6H(2)O complex. A series of poly-substituted 1,2,4-triazolines compounds were obtained in moderate to excellent yields (70-99%) with excellent enantioselectivities (82-98% ee).
引用
收藏
页码：4077 / 4079
页数：3
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