Role of the third intracellular loop of CXCR4 in SDF-1-mediated signaling

被引：0

作者：

Ahr, B ^{[1
]}

Robert-Hebmann, V ^{[1
]}

Roland, J ^{[1
]}

Murphy, BJ ^{[1
]}

Devaux, C ^{[1
]}

Biard-Piechaczyk, M ^{[1
]}

机构：

[1] Inst Biol, CNRS, Lab UMR 5121, Montpellier, France

来源：

XIV INTERNATIONAL AIDS CONFERENCE: BASIC SCIENCES | 2002年

关键词：

D O I：

暂无

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The CXCR4 chemokine receptor is a Gi protein-coupled receptor that triggers multiple intracellular signals in response to SDF-1. In this study, we explored the role played by the third intracellular loop (ICL3) of CXCR4 in SDF-1-mediated signaling using human embryonic kidney (HEK)293 cells stably expressing wild type or a mutated form of CXCR4. We demonstrated here that ICL3 is specifically involved in Gi-dependent signals.

引用

页码：1 / 6

页数：6

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