Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development

被引：116

作者：

Brzezinski, Joseph A. ^{[1
]}

Lamba, Deepak A. ^{[1
]}

Reh, Thomas A. ^{[1
]}

机构：

[1] Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA

来源：

DEVELOPMENT | 2010年 / 137卷 / 04期

关键词：

Blimp1 (Prdm1); Retina; Cell fate determination; Photoreceptor; Rod; Cone; Bipolar cell; Mouse; HOMEOBOX GENE VSX1; PROGENITOR CELLS; MOUSE RETINA; TRANSCRIPTIONAL REPRESSION; NEURAL RETINA; PLASMA-CELLS; GERM-CELLS; RAT RETINA; EXPRESSION; DIFFERENTIATION;

D O I：

10.1242/dev.043968

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Photoreceptors, rods and cones are the most abundant cell type in the mammalian retina. However, the molecules that control their development are not fully understood. In studies of photoreceptor fate determination, we found that Blimp1 (Prdm1) is expressed transiently in developing photoreceptors. We analyzed the function of Blimp1 in the mouse retina using a conditional deletion approach. Developmental analysis of mutants showed that Otx2(+) photoreceptor precursors ectopically express the bipolar cell markers Chx10 (Vsx2) and Vsx1, adopting bipolar instead of photoreceptor fate. However, this fate shift did not occur until the time when bipolar cells are normally specified during development. Most of the excess bipolar cells died around the time of bipolar cell maturation. Our results suggest that Blimp1 expression stabilizes immature photoreceptors by preventing bipolar cell induction. We conclude that Blimp1 regulates the decision between photoreceptor and bipolar cell fates in the Otx2(+) cell population during retinal development.

引用

页码：619 / 629

页数：11

共 64 条

[1] Targeting of GFP to newborn rods by Nrl promoter and temporal expression profiling of flow-sorted photoreceptors [J].

Akimoto, M ;

Cheng, H ;

Zhu, DX ;

Brzezinski, JA ;

Khanna, R ;

Filippova, E ;

Oh, ECT ;

Jing, YZ ;

Linares, JL ;

Brooks, M ;

Zareparsi, S ;

Mears, AJ ;

Hero, A ;

Glaser, T ;

Swaroop, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (10) :3890-3895

[2] Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells [J].

Ancelin, Katia ;

Lange, Ulrike C. ;

Hajkova, Petra ;

Schneider, Robert ;

Bannister, Andrew J. ;

Kouzarides, Tony ;

Surani, M. Azim .

NATURE CELL BIOLOGY, 2006, 8 (06) :623-630

[3] The transcription factor Bhlhb4 is required for rod bipolar cell maturation [J].

Bramblett, DE ;

Pennesi, ME ;

Wu, SM ;

Tsai, MJ .

NEURON, 2004, 43 (06) :779-793

[4] Loss of circadian photoentrainment and abnormal retinal electrophysiology in Math5 mutant mice [J].

Brzezinski, JA ;

Brown, NL ;

Tanikawa, A ;

Bush, RA ;

Sieving, PA ;

Vitaterna, MH ;

Takahashi, JS ;

Glaser, T .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46 (07) :2540-2551

[5] Ocular retardation mouse caused by Chx10 homeobox null allele: Impaired retinal progenitor proliferation and bipolar cell differentiation [J].

Burmeister, M ;

Novak, T ;

Liang, MY ;

Basu, S ;

Ploder, L ;

Hawes, NL ;

Vidgen, D ;

Hoover, F ;

Goldman, D ;

Kalnins, VI ;

Roderick, TH ;

Taylor, BA ;

Hankin, MH ;

McInnes, RR .

NATURE GENETICS, 1996, 12 (04) :376-384

[6] Regulatory mechanisms that determine the development and function of plasma cells [J].

Calame, KL ;

Lin, KI ;

Tunyaplin, C .

ANNUAL REVIEW OF IMMUNOLOGY, 2003, 21 :205-230

[7] RODS AND CONES IN THE MOUSE RETINA .2. AUTORADIOGRAPHIC ANALYSIS OF CELL GENERATION USING TRITIATED-THYMIDINE [J].

CARTERDAWSON, LD ;

LAVAIL, MM .

JOURNAL OF COMPARATIVE NEUROLOGY, 1979, 188 (02) :263-272

[8] The dynamic expression pattern of B lymphocyte induced maturation protein-1 (Blimp-1) during mouse embryonic development [J].

Chang, DH ;

Calame, KL .

MECHANISMS OF DEVELOPMENT, 2002, 117 (1-2) :305-309

[9] Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes [J].

Chen, SM ;

Wang, QL ;

Nie, ZQ ;

Sun, H ;

Lennon, G ;

Copeland, NG ;

Gilbert, DJ ;

Jenkins, NA ;

Zack, DJ .

NEURON, 1997, 19 (05) :1017-1030

[10] Control of late off-center cone bipolar cell differentiation and visual signaling by the homeobox gene Vsx1 [J].

Chow, RL ;

Volgyi, B ;

Szilard, RK ;

Ng, D ;

McKerlie, C ;

Bloomfield, SA ;

Birch, DG ;

McInnes, RR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (06) :1754-1759

← 1 2 3 4 5 6 7 →