Macathiohydantoins B-K, novel thiohydantoin derivatives from Lepidium meyenii

被引：17
|
作者：
Yu, Mu-Yuan [1 ,2 ,3 ]
Qin, Xu-Jie [1 ,3 ]
Peng, Xing-Rong [1 ,3 ]
Wang, Xia [1 ,2 ,3 ]
Tian, Xiao-Xue [1 ,3 ]
Li, Zhong-Rong [1 ,3 ]
Qiu, Ming-Hua [1 ,3 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China
来源：
TETRAHEDRON | 2017年 / 73卷 / 30期
关键词：
Brassicaceae; Lepidium meyenii; Maca; Thiohydantoin derivatives; MACA; CONSTITUENTS;
D O I：
10.1016/j.tet.2017.05.096
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Macathiohydantoins B-K (1-10), two new group of naturally occurring thiohydantoin derivatives, together with one known analogues (11), were isolated from the rhizomes of Lepidium meyenii (Maca). Compounds 1-11 were all initially obtained as racemic mixtures and further separated by chiral HPLC chromatography to afford the eleven pairs of enantiomers. The structures of 1-10 including their absolute configurations were fully established by the comprehensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. All isolates were evaluated for their cytotoxic and antimicrobial activities. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4392 / 4397
页数：6
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