Synthesis of deuterium-labeled pregabalin

被引：0
|
作者：
Shen, Zucheng [3 ]
Wu, Wenchao [4 ]
Wang, Wei [3 ]
Chen, Liqin [1 ,2 ]
机构：
[1] Nanjing Univ Technol, Hitech Res Inst, Nanjing 210009, Jiangsu, Peoples R China
[2] Nanjing Univ Technol, State Key Lab Mat Oriented Chem Engn, Nanjing 210009, Jiangsu, Peoples R China
[3] Nanjing Univ Technol, Sch Pharmaceut Sci, Nanjing 210009, Jiangsu, Peoples R China
[4] Nanjing Univ Technol, Sch Biotechnol & Pharmaceut Engn, Nanjing 210009, Jiangsu, Peoples R China
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2011年 / 54卷 / 13期
关键词：
deuterium; labeled; synthesis; pregabalin;
D O I：
10.1002/jlcr.1936
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
This paper describes the synthesis of deuterium-labeled pregabalin. The stable isotopic-labeled compound was obtained in nine steps starting from the commercially available 4-[2H11]methylvaleric acid as the stable-labeled reagent. It is used as an internal standard for analysis and metabolic studies.
引用
收藏
页码：809 / 812
页数：4
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