Susceptibility of human enterotoxigenic Escherichia coli isolates to growth inhibition by porcine intestinal epithelial cells

被引:3
|
作者
Brown, Eric A. [1 ]
Kaushik, Radhey S. [1 ]
Hardwidge, Philip R. [1 ]
机构
[1] S Dakota State Univ, Ctr Infect Dis Res & Vaccinol, Brookings, SD 57007 USA
关键词
ETEC; IPEC-J2; cationic antimicrobial molecule; bacterial pathogenesis;
D O I
10.1111/j.1574-6968.2007.00814.x
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Growth of human, but not porcine enterotoxigenic Escherichia coli (ETEC) isolates is inhibited during incubation with porcine intestinal epithelial cells and by a constitutively produced factor(s) present in unstimulated cell supernatants. The inhibitory factor(s) is heat stable, not produced by serum-starved cells, and is present in a diverse number of cultured epithelial cell lines of animal, but not of human origin. Susceptibility to porcine intestinal epithelial cells appears to be restricted to ETEC and not E. coli O157:H7 disease isolates.
引用
收藏
页码:95 / 101
页数:7
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