Solvent-Free Selective Condensations Based on the Formation of the Olefinic (C=C) Bond Catalyzed by Organocatalyst

被引：4
|
作者：
Song, Heyuan [1 ,2 ]
Jin, Ronghua [1 ]
Jin, Fuxiang [1 ]
Kang, Meirong [1 ]
Li, Zhen [1 ]
Chen, Jing [1 ]
机构：
[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
[2] Univ Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
来源：
Catalysts | 2016年 / 6卷 / 07期
基金：
中国国家自然科学基金;
关键词：
aldol condensation; Knoevenagel condensation; organocatalysis; solvent-free condition; ketone; aldehyde; ASYMMETRIC ALDOL REACTIONS; IONIC LIQUID; KNOEVENAGEL REACTION; ALDEHYDES; KETONES; ALPHA;
D O I：
10.3390/catal6070106
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Pyrrolidine and its derivatives were used to catalyze aldol and Knoevenagel condensations for the formation of the olefinic (C = C) bond under solvent-free conditions. The 3-pyrrolidinamine showed high activity and afforded excellent yields of alpha, beta-unsaturated compounds. The aldol condensation of aromatic/heterocyclic aldehydes with ketones affords enones in high conversion (99.5%) and selectivity (92.7%). Good to excellent yields of alpha, beta-unsaturated compounds were obtained in the Knoevenagel condensation of aldehydes with methylene-activated substrates.
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页数：8
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