Upregulation of ZBTB7A exhibits a tumor suppressive role in gastric cancer cells

被引：16

作者：

Sun, Guang ^{[1
]}

Peng, Bo ^{[1
]}

Xie, Quan ^{[1
]}

Ruan, Jianwen ^{[1
]}

Liang, Xianwen ^{[1
]}

机构：

[1] Cent S Univ, Dept Surg Gastroenterol, Affiliated Haikou Hosp, Haikou Municipal Peoples Hosp,Xiangya Sch Med, 43 Renmin Rd, Haikou 570208, Hainan, Peoples R China

来源：

MOLECULAR MEDICINE REPORTS | 2018年 / 17卷 / 02期

关键词：

gastric cancer; zinc finger and BTB domain containing 7A; apoptosis; migration; cell cycle; LEUKEMIA/LYMPHOMA-RELATED FACTOR; COPY-NUMBER ALTERATION; TRANSCRIPTIONAL REPRESSOR; GENE-EXPRESSION; LUNG-CANCER; POZ DOMAIN; OVEREXPRESSION; METASTASIS; POKEMON; PROTEIN;

D O I：

10.3892/mmr.2017.8104

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastric cancer presents as a complex solid tumor and is the third leading cause of global cancer-associated mortality. The genetic alterations in gastric cancer remain unclear and deserve further investigation. Mining The Cancer Genome Atlas gastric adenocarcinoma dataset identified a frequent loss of the zinc finger and BTB domain containing 7A (ZBTB7A) gene locus and a significant correlation between low ZBTB7A expression and poor patient survival. ZBTB7A belongs to the POZ/BTB and Kruppel transcription factor family. In the present study, overexpression of ZBTB7A in a gastric cancer cell line induced cell cycle arrest at the S phase. Upregulation of ZBTB7A also promoted apoptosis and repressed cell migration. The results of the present study indicated that ZBTB7A functions as a tumor suppressor in gastric cancer cells. Understanding the role of ZBTB7A in gastric cancer may provide important clinical insight for treatment.

引用

页码：2635 / 2641

页数：7