Structure-activity relationship studies of the chromosome segregation inhibitor, Incentrom A

被引：8

作者：

Lee, Hee-Yoon ^{[1
,2
]}

Jung, Yongsik ^{[1
,2
]}

Kim, Wonyeob ^{[1
,2
]}

Kim, Jin Hee ^{[3
]}

Suh, Min-Soo ^{[3
]}

Shin, Seung Koo ^{[3
]}

Yoon, Hye-Joo ^{[3
]}

机构：

[1] Korea Adv Inst Sci & Technol, Dept Chem, Taejon 305701, South Korea

[2] Korea Adv Inst Sci & Technol, Sch Mol Sci BK21, Taejon 305701, South Korea

[3] Pohang Univ Sci & Technol, Dept Chem, Bionanotechnol Ctr, Pohang 790784, Kyungbuk, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 16期

关键词：

inhibition; chromosome segregation; yeast; structure-activity relationship; pharmacophore; incentrom A;

D O I：

10.1016/j.bmcl.2008.07.006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of Incentrom A analogs that inhibit the chromosome segregation process in yeast were synthesized and tested for their effects on chromosome stability and cell proliferation. Pharmacophore and structure-activity relationship of Incentrom A for the anti-yeast activity were established. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4670 / 4674

页数：5

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