Novel and Efficient Method for the Synthesis of Racemic Fexofenadine

被引：3

作者：

Raghavendra, G. M. ^{[1
]}

Harsha, K. B. ^{[1
]}

Vinaya, K. ^{[1
]}

Mantelingu, K. ^{[1
]}

Rangappa, K. S. ^{[1
]}

机构：

[1] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India

来源：

SYNTHETIC COMMUNICATIONS | 2011年 / 41卷 / 15期

关键词：

Fexofenadine; H1-histamine receptor; histamine antagonists; tetrafenadine; FACILE SYNTHESIS; TERFENADINE; H-1-ANTIHISTAMINES; HISTAMINE; ARTHRITIS; RELEASE; FLUID;

D O I：

10.1080/00397911.2010.502986

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[image omitted] Fexofenadine is a selective H1-histamine receptor antagonist, which is an attractive alternative treatment for allergy symptoms. An efficient and environmentally friendly synthetic approach for the preparation of fexofenadine was developed from commercially available cumene. The method involves the Friedel-Craft's reaction, substitution, reduction, bromination, and the Grignard reaction.

引用

页码：2296 / 2303

页数：8

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