Synthesis of Cationic Alkyl Glycerolipids with Heterocyclic Nitrogen-Containing Bases as Polar Domains

被引：4
|
作者：
Plyavnik, N. V. [1 ]
Kramareva, T. V. [1 ]
Serebrennikova, G. A. [1 ]
机构：
[1] Lomonosov State Acad Fine Chem Technol, Moscow 119571, Russia
来源：
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY | 2011年 / 37卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
antitumor lipids; positively charged glycerolipids; cationic heterocyclic heads; ET-18-OCH3; EDELFOSINE; APOPTOSIS; DEATH; CELLS;
D O I：
10.1134/S1068162011040108
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Synthesis of new cationic alkyl glycerolipids with potential antitumor properties is described, their polar domain being heterocyclic nitrogen-containing bases of various types. A synthetic scheme for cationic lipids containing aliphatic short-chain substituents in the heterocyclic polar head is proposed.
引用
收藏
页码：492 / 498
页数：7
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