The AMPK-induced p70S6K inhibition participates in the synergistic effect of biguanides and insulin on glucose uptake via the overphosphorylation of the PKB/AS160 axis

被引:0
|
作者
Beauloye, Christophe [1 ]
Ginion, Audrey [1 ]
Mouton, Celine [1 ]
Hue, Louis [2 ]
Vanoverschelde, Jean-Louis [1 ]
Bertrand, Luc [1 ]
机构
[1] Univ Catholique Louvain, Div Cardiol, B-1200 Brussels, Belgium
[2] Univ Catholique Louvain, Christian Duve Inst Cellular Pathol, Hormone & Metab Res Unit, B-1200 Brussels, Belgium
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:135 / 135
页数:1
相关论文
共 32 条
  • [1] The AMPK-induced P70S6K inhibition participates in the synergistic effect of biguanides and insulin on glucose uptake via the overphosphorylation of the PKB/AS160 axis
    Ginion, A.
    Beauloye, C.
    Mouton, C.
    Hue, L.
    Vanoverschelde, J. -L.
    Bertrand, L.
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2008, 38 : 47 - 47
  • [2] The AMPK-induced p70S6K inhibition correlates to the synergistic effect of biguanides and insulin on glucose uptake via the overphosphorylation of the PKB/AS160 axis
    Bertrand, L.
    Ginion, A.
    Beauloye, C.
    Mouton, C.
    Hue, L.
    Vanoverschelde, J-L.
    DIABETOLOGIA, 2007, 50 : S232 - S232
  • [3] Inhibition of the mTOR/p70S6K pathway is not involved in the insulin-sensitizing effect of AMPK on cardiac glucose uptake
    Ginion, Audrey
    Auquier, Julien
    Benton, Carley R.
    Mouton, Celine
    Vanoverschelde, Jean-Louis
    Hue, Louis
    Horman, Sandrine
    Beauloye, Christophe
    Bertrand, Luc
    AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2011, 301 (02): : H469 - H477
  • [4] The Inhibition of the Insulin Negative Feedback Loop Implicating p70S6K Is Not Involved in the Insulin-Sensitizing Effect of AMPK Activators on Cardiac Glucose Uptake
    Ginion, Audrey
    Auquier, Julien
    Hue, Louis
    Horman, Sandrine
    Beauloye, Christophe
    Vanoverschelde, Jean-Louis
    Bertrand, Luc
    DIABETES, 2010, 59 : A383 - A383
  • [5] Cardioprotection afforded by insulin and ischemic preconditioning is abolished by inhibition of pkb and p70s6k
    Fuglesteg, BN
    Trion, C
    Mjos, OD
    Jonassen, AK
    JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2005, 38 (06) : 1087 - 1087
  • [6] The axis activation mTOR/p70S6K by leucine reduced the stimulation of insulin signaling in flies but not glucose transport in response to insulin in cardiomyocytes
    Auquier, J.
    Ginion, A.
    Hue, L.
    Vanoverschelde, J. -L.
    Horman, S.
    Beauloye, C.
    Bertrand, L.
    DIABETES & METABOLISM, 2012, 38 : A74 - A74
  • [7] Metformin alleviates dexamethasone-induced apoptosis by regulating autophagy via AMPK/mTOR/p70S6K in osteoblasts
    Guo, Xintong
    Liang, Min
    EXPERIMENTAL CELL RESEARCH, 2022, 415 (01)
  • [8] Activation of AMPK by Telmisartan Decreases Basal and PDGF-stimulated VSMC Proliferation via Inhibiting the mTOR/p70S6K Signaling Axis
    Hwang, Yun-Jin
    Park, Jung-Hyun
    Cho, Du-Hyong
    JOURNAL OF KOREAN MEDICAL SCIENCE, 2020, 35 (35)
  • [9] Deletion of AMPK-Alpha2 intensifies the insulin-induced p70S6K activation in normoxic heart and the isoproterenol-induced ventricular hypertrophy
    Zarrinpashneh, Elham
    Beauloye, Christophe
    Ginion, Audrey
    Pouleur, Anne-Catherine
    Horman, Sandrine
    Hue, Louis
    Viollet, Benoit
    Vanoverschelde, Jean-Louis J.
    Bertrand, Luc
    CIRCULATION, 2006, 114 (18) : 6 - 6
  • [10] AMPK/mTOR/p70S6K axis prevents apoptosis of Porphyromonas gingivalis-infected gingival epithelial cells via BadSer136 phosphorylation
    Wang, Yanchun
    Dong, Yilong
    Zhang, Wenbo
    Wang, Yanmei
    Jao, Yang
    Liu, Jianjun
    Zhang, Mingzhu
    He, Hongbing
    APOPTOSIS, 2023, 28 (7-8) : 1012 - 1023