Longitudinal analysis of antibody response following SARS-CoV-2 infection in pregnancy: From the first trimester to delivery

被引：16
|
作者：
Cosma, Stefano [1 ]
Carosso, Andrea Roberto [1 ]
Corcione, Silvia [2 ,3 ]
Cusato, Jessica [4 ]
Borella, Fulvio [1 ]
Antonucci, Miriam [4 ]
Marozio, Luca [1 ]
Revelli, Alberto [1 ]
Preti, Mario [1 ]
Ghisetti, Valeria [5 ]
Di Perri, Giovanni [6 ]
Benedetto, Chiara [1 ]
机构：
[1] Univ Turin, Dept Surg Sci, City Hlth & Sci, Gynecol & Obstet 1, Turin, Italy
[2] Univ Turin, Dept Med Sci, Infect Dis, Turin, Italy
[3] Tufts Univ, Sch Med, Boston, MA 02111 USA
[4] Univ Turin, Amedeo Savoia Hosp, Dept Med Sci, Lab Clin Pharmacol & Pharmacogenet, Turin, Italy
[5] ASL Citta Torino, Amedeo Savoia Hosp, Lab Microbiol & Virol, Turin, Italy
[6] Univ Turin, Amedeo Savoia Hosp, Dept Med Sci, Unit Infect Dis, Turin, Italy
来源：
JOURNAL OF REPRODUCTIVE IMMUNOLOGY | 2021年 / 144卷
关键词：
SARS-CoV-2; Pregnancy; Antibodies; COVID-19; immunology; vaccines;
D O I：
10.1016/j.jri.2021.103285
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We report herein the longest-lasting study of SARS-CoV-2 antibody profile in pregnancy, from first trimester infection to delivery. Seventeen out of 164 pregnant women tested positive for COVID-19. Throughout pregnancy, the neutralizing antibody titer remained stable, whilst a significant decline in the non-neutralizing antibodies was observed after 16 weeks of gestation. All the newborns of women who developed IgG antibodies showed the presence of the same antibodies in arterial cord blood. Knowledge on the longevity and type of SARSCoV-2 antibody response may help to guide vaccination strategies in pregnancy.
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页数：3
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