CR1 genotype is associated with entorhinal cortex volume in young healthy adults

被引：30
|
作者：
Bralten, Janita [1 ,2 ]
Franke, Barbara [2 ,3 ]
Arias-Vasquez, Alejandro [2 ,3 ]
Heister, Angelien [2 ]
Brunner, Han G. [2 ]
Fernandez, Guillen [1 ,4 ]
Rijpkema, Mark [1 ]
机构：
[1] Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Ctr Cognit Neuroimaging, NL-6525 ED Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, NL-6525 ED Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Med Ctr, Donders Inst Brain Cognit & Behav, Dept Psychiat, NL-6525 ED Nijmegen, Netherlands
[4] Radboud Univ Nijmegen, Med Ctr, Dept Cognit Neurosci, NL-6525 ED Nijmegen, Netherlands
来源：
NEUROBIOLOGY OF AGING | 2011年 / 32卷 / 11期
关键词：
Complement receptor 1; Alzheimer's disease; Imaging genetics; magnetic resonance imaging (MRI); Voxel-based morphometry; Medial temporal lobe; GENOME-WIDE ASSOCIATION; ALZHEIMERS-DISEASE; IDENTIFIES VARIANTS; FIELD-STRENGTH; ATROPHY; BRAIN; PROTEINS; PATHWAY; ALLELE; CLU;
D O I：
10.1016/j.neurobiolaging.2011.05.017
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Gene-brain structure associations of 3 recently discovered risk genes for Alzheimer's disease, CLU (rs11136000C > T), CR1 (rs6656401G > A), and PICALM (rs38511790 > A), were investigated in 2 independent cohorts of young healthy adults (n = 430 and n = 492, respectively). We assessed structural differences in 2 core structures of Alzheimer pathology, entorhinal cortex and hippocampus, by voxel-based moiphometry using high-resolution magnetic resonance imaging (MRI) data. For CLU and PICALM no significant genotype-related differences in local gray matter volume were found. CR1 risk allele (A) carriers showed smaller local gray matter volume in the entorhinal cortex, as confirmed in both cohorts. This association, apparent in young healthy adults, might mediate susceptibility for Alzheimer's disease later in life. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：2106.e7 / 2106.e11
页数：5
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