Mesenchymal stem cells derived secretome as an innovative cell-free therapeutic approach

被引：1
|
作者：
Abu-El-Rub, Ejlal [1 ,2 ]
Khasawneh, Ramada R. [1 ]
Almahasneh, Fatimah A. [1 ]
Zegallai, Hana M. [3 ,4 ]
机构：
[1] Yarmouk Univ, Fac Med, Dept Basic Med Sci, Irbid 21163, Jordan
[2] Univ Manitoba, Fac Med, Physiol & Pathophysiol, Winnipeg, MB R3E 0W2, Canada
[3] Univ Manitoba, Dept Pharmacol & Therapeut, Winnipeg, MB R3E 0W2, Canada
[4] Childrens Hosp Res Inst Manitoba, DREAM, Winnipeg, MB R3E 0W2, Canada
来源：
BIOCELL | 2022年 / 46卷 / 04期
关键词：
Mesencyhmal stem cells; Secretome; Immuno-modulation; Cytokines; Growth factors; PARACRINE MECHANISMS;
D O I：
10.32604/biocell.2022.018306
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The paracrine and immunomodulatory cytokines secreted by mesenchymal stem cells (MSCs), generally referred to as the MSCs derived secretome, has substantial potential for the treatment of many chronic and degenerative diseases. MSCs secretome contains both common and disease specific cytokines and modulators that can be beneficial against a wide range of chronic diseases. Herein, we discuss the MSCs secretome composition profile and its translational applicability and the challenges surrounding its use in clinical settings.
引用
收藏
页码：907 / 911
页数：5
相关论文
共 50 条
  • [1] Mesenchymal Stem Cell Secretome: Cell-free Therapeutic Strategy in Regenerative Medicine
    Meiliana, Anna
    Dewi, Nurrani Mustika
    Wijaya, Andi
    INDONESIAN BIOMEDICAL JOURNAL, 2019, 11 (02): : 113 - 124
  • [2] Mesenchymal stem cells secretome: The cornerstone of cell-free regenerative medicine
    Gonzalez-Gonzalez, Alberto
    Garcia-Sanchez, Daniel
    Dotta, Monica
    Rodriguez-Rey, Jose C.
    Perez-Campo, Flor M.
    WORLD JOURNAL OF STEM CELLS, 2020, 12 (12): : 1529 - 1552
  • [3] Mesenchymal Stem Cell Secretome: Toward Cell-Free Therapeutic Strategies in Regenerative Medicine
    Vizoso, Francisco J.
    Eiro, Noemi
    Cid, Sandra
    Schneider, Jose
    Perez-Fernandez, Roman
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (09)
  • [4] Mesenchymal stem cell-derived secretome and microvesicles as a cell-free therapeutics for neurodegenerative disorders
    Hyun Ok Kim
    Seong-Mi Choi
    Han-Soo Kim
    Tissue Engineering and Regenerative Medicine, 2013, 10 : 93 - 101
  • [5] Mesenchymal Stem Cell-Derived Secretome and Microvesicles as a Cell-Free Therapeutics for Neurodegenerative Disorders
    Kim, Hyun Ok
    Choi, Seong-Mi
    Kim, Han-Soo
    TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2013, 10 (03) : 93 - 101
  • [6] The mesenchymal stem cell secretome: A new paradigm towards cell-free therapeutic mode in regenerative medicine
    Kumar, Praveen L.
    Kandoi, Sangeetha
    Misra, Ranjita
    Vijayalakshmi, S.
    Rajagopal, K.
    Verma, Rama Shanker
    CYTOKINE & GROWTH FACTOR REVIEWS, 2019, 46 : 1 - 9
  • [7] Production of mesenchymal stem cell derived-secretome as cell-free regenerative therapy and immunomodulation: A biomanufacturing perspective
    Torizal, Fuad Gandhi
    Kerans, Fransiscus Fiano Anthony
    Khumaira, Annisa
    BIOCELL, 2022, 46 (08) : 1885 - 1891
  • [8] The secretome of mesenchymal stem cells and oxidative stress: challenges and opportunities in cell-free regenerative medicine
    Bahareh Rahimi
    Mohammad Panahi
    Neda Saraygord-Afshari
    Neda Taheri
    Merve Bilici
    Davod Jafari
    Effat Alizadeh
    Molecular Biology Reports, 2021, 48 : 5607 - 5619
  • [9] Disagreements in the therapeutic use of mesenchymal stem cell- derived secretome
    Sipos, Ferenc
    Muzes, Gyorgyi
    WORLD JOURNAL OF STEM CELLS, 2022, 14 (06): : 365 - 371
  • [10] The secretome of mesenchymal stem cells and oxidative stress: challenges and opportunities in cell-free regenerative medicine
    Rahimi, Bahareh
    Panahi, Mohammad
    Saraygord-Afshari, Neda
    Taheri, Neda
    Bilici, Merve
    Jafari, Davod
    Alizadeh, Effat
    MOLECULAR BIOLOGY REPORTS, 2021, 48 (07) : 5607 - 5619
12345