Adverse Childhood Experiences Predict Common Neurodevelopmental and Behavioral Health Conditions among U.S. Children

被引:28
|
作者
Zarei, Kasra [1 ]
Xu, Guifeng [2 ]
Zimmerman, Bridget [3 ]
Giannotti, Michele [4 ]
Strathearn, Lane [1 ,5 ,6 ]
机构
[1] Univ Iowa, Ctr Disabil & Dev, Stead Family Childrens Hosp, Iowa City, IA 52242 USA
[2] Univ Iowa, Dept Epidemiol, Coll Publ Hlth, Iowa City, IA 52242 USA
[3] Univ Iowa, Dept Biostat, Coll Publ Hlth, Iowa City, IA 52242 USA
[4] Univ Trento, Dept Psychol & Cognit Sci, Via Calepina 14, I-38122 Trento, Italy
[5] Univ Iowa, Stead Family Dept Pediat, Carver Coll Med, Iowa City, IA 52242 USA
[6] Univ Iowa, Hawkeye Intellectual & Dev Disabil Res Ctr Hawk I, Iowa City, IA 52242 USA
来源
CHILDREN-BASEL | 2021年 / 8卷 / 09期
关键词
childhood adversity; trauma; adverse childhood experiences; neurodevelopment; behavioral health; POSTTRAUMATIC-STRESS-DISORDER; HOUSEHOLD DYSFUNCTION; MATERNAL SENSITIVITY; ADHD DIAGNOSIS; MENTAL-HEALTH; SYMPTOMS; ABUSE; RISK; DEPRESSION; URBAN;
D O I
10.3390/children8090761
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Objective: Adverse childhood experiences (ACEs) can have a significant but variable effect on childhood neurodevelopment. The purpose of this study was to quantify and compare the associations between "household challenge" ACEs and common childhood neurodevelopmental and behavioral health conditions, using nationally representative U.S. data. Method: This study used data from the 2016-2019 National Survey of Children's Health, a nationwide, population-based, cross-sectional survey. Seven household challenge ACEs (not including child maltreatment) were reported by parents/guardians: parental death, incarceration, divorce/separation, family violence, mental illness, substance abuse, and poverty. Logistic regression with sample weights was used to estimate the odds ratio (OR) for 15 parent-reported neurodevelopmental and behavioral health conditions, by the number of reported ACEs. A dose-response relationship was examined by applying tests of orthogonal polynomial contrasts to fitted logistic regression models. Results: Down syndrome, Tourette syndrome and cerebral palsy were not associated with household challenge ACEs, whereas behavior/conduct problems, depression, and substance abuse were strongly associated, with adjusted ORs ranging from 6.36 (95% confidence interval (CI) 5.53, 7.32) to 9.19 (95% CI 7.79, 10.84). Other neurodevelopmental conditions not traditionally associated with childhood adversity showed moderate yet robust associations with ACEs, including autism (adjusted OR 2.15, 95% CI 1.64, 2.81), learning disability (adjusted OR 3.26, 95% CI 2.80, 3.80), and attention deficit hyperactivity disorder (adjusted OR 3.95, 95% CI 3.44, 4.53). The ORs increased with the number of ACEs, showing significant positive linear trends. Conclusion: We found significant dose-dependent or cumulative associations between ACEs and multiple neurodevelopmental and behavioral conditions.
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页数:13
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