Daptomycin non-susceptible meticillin-resistant Staphylococcus aureus USA 300 isolate

被引：66

作者：

Murthy, Madhukiran H. ^{[1
]}

Olson, Michael E. ^{[2
]}

Wickert, Robert W. ^{[2
]}

Fey, Paul D. ^{[2
]}

Jalali, Ziba ^{[1
]}

机构：

[1] Univ Nebraska Med Ctr, Dept Internal Med & Infect Dis, Omaha, NE 68198 USA

[2] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 2008年 / 57卷 / 08期

关键词：

D O I：

10.1099/jmm.0.2008/000588-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Daptomycin is a novel bactericidal agent active against Gram-positive pathogens including meticillin-resistant Staphylococcus aureus (MRSA). Our case is unique in the description of an MRSA USA 300 isolate that developed decreased susceptibility to daptomycin during daptomycin and vancomycin therapy. Directed sequencing detected a previously reported mutation in mprF, resulting in a T345A substitution, associated with non-susceptibility to daptomycin.

引用

页码：1036 / 1038

页数：3

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