Autocatalytic asymmetric reduction of 2,6-diacetylpyridine

被引：5

作者：

Panosyan, FB ^{[1
]}

Chin, J ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 21期

关键词：

D O I：

10.1021/ol035515k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] We report here that the C-2-symmetric diol 2,6-bis(1-hydroxyethyl)pyridine (2) can effect chiral-catalyzed reduction of 2,6-diacetylpyridine (1) and produce more of the diol (2) with the same configuration in an enantiomerically enriched form. The two carbonyl functionalities of (1) are reduced in 90% conversion to produce the enantio-enriched C-2-symmetric diol (40% ee, 47% de) using zinc trifluoromethanesuffonate and a catalytic amount of the chiral C-2-symmetric diol (2).

引用

页码：3947 / 3949

页数：3

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