Pharmacokinetics and tissue distribution of anidulafungin in rats

被引：46
|
作者：
Damle, Bharat [1 ]
Stogniew, Martin [2 ]
Dowei, James [2 ]
机构：
[1] Pfizer Inc, Clin Pharmacol, Global Res & Dev, New York, NY 10017 USA
[2] Vicuron Pharmaceut, New York, NY USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2008年 / 52卷 / 07期
关键词：
D O I：
10.1128/AAC.01596-07
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
This study assessed the tissue distribution of anidulafungin in rats. Anidulafungin rapidly distributed into tissues, achieving peak concentrations within 30 min, and maintained levels above MICs for common pathogens over 72 h. In tissues susceptible to fungal infection (liver, lung, spleen, kidney), exposure was 9- to 12-fold higher than in plasma.
引用
收藏
页码：2673 / 2676
页数：4
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