Hypogonadotropic hypogonadism

被引：33
|
作者：
Hayes, FJ
Seminara, SB
Crowley, WF
机构：
[1] Massachusetts Gen Hosp, Reprod Endocrine Unit, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Natl Ctr Infertil Res, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Boston, MA USA
来源：
ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 1998年 / 27卷 / 04期
关键词：
D O I：
10.1016/S0889-8529(05)70039-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This article outlines the changing pattern of gonadotropin-releasing hormone (GnRH)-induced gonadotropin secretion across sexual development, a knowledge of which is critical to understanding GnRH secretion in pathologic states such as hypogonadotropic hypogonadism. The clinical presentation, differential diagnosis, and treatment of hypogonadotropic hypogonadism in humans are discussed. Particular emphasis is placed on the contribution of frequent sampling studies of gonadotropin secretion and genetic studies to understanding the pathophysiology and clinical heterogeneity of isolated GnRH deficiency in humans.
引用
收藏
页码：739 / +
页数：26
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