Regiodivergent Synthesis of 3,4-and 4,5-Disubstituted N-Methylpyrazoles from 4-Acyl-1H-pyrrole-2,3-dione and Methylhydrazine

被引：5
|
作者：
Poletto, Julia [1 ]
da Silva, Michael J. V. [1 ]
Pianoski, Karlos E. [1 ]
Willig, Julia C. M. [1 ]
Rosa, Fernanda A. [1 ]
机构：
[1] Univ Estadual Maringa UEM, Dept Quim, BR-87030900 Maringa, Parana, Brazil
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2022年 / 87卷 / 13期
关键词：
PYRAZOLE; REACTIVITIES; ANTIFUNGAL; ETHYL;
D O I：
10.1021/acs.joc.2c00657
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, efficient and highly regioselective method for the preparation of 3,4-and 4,5-disubstituted N-methylpyrazoles in a one-pot procedure is reported. The methodology developed was based on the regiochemical control of the reaction of 4-acyl-1H-pyrrole-2,3-diones and methylhydrazine with an influence of the addition or absence of acid and the substrate structure.
引用
收藏
页码：8544 / 8550
页数：7
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