Direct Short-Term Cytotoxic Effects of BIBR 1532 on Acute Promyelocytic Leukemia Cells Through Induction of p21 Coupled with Downregulation of c-Myc and hTERT Transcription

被引：32

作者：

Bashash, D. ^{[1
,2
]}

Ghaffari, S. H. ^{[1
]}

Zaker, F. ^{[2
]}

Hezave, K. ^{[2
]}

Kazerani, M. ^{[2
]}

Ghavamzadeh, A. ^{[1
]}

Alimoghaddam, K. ^{[1
]}

Mosavi, S. A. ^{[1
]}

Gharehbaghian, A. ^{[3
]}

Vossough, P. ^{[4
]}

机构：

[1] Univ Tehran Med Sci, Hematol Oncol & Stem Cell Transplantat Res Ctr, Tehran, Iran

[2] Univ Tehran Med Sci, Fac Allied Med, Dept Hematol, Tehran, Iran

[3] Shihid Beheshti Univ Med Sci, Fac Allied Med, Dept Lab Med, Tehran, Iran

[4] Univ Tehran Med Sci, Dept Hematol, Hazrate Aliasghar Childrens Hosp, Tehran, Iran

来源：

CANCER INVESTIGATION | 2012年 / 30卷 / 01期

关键词：

BIBR; 1532; Telomerase; hTERT; c-Myc; p21; APL; NB4; TELOMERASE ACTIVITY; HUMAN CANCER; INDUCED APOPTOSIS; INHIBITION; DEATH; THERAPEUTICS; DYSFUNCTION; SURVIVAL; PATHWAY; GROWTH;

D O I：

10.3109/07357907.2011.629378

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute promyelocytic leukemia (APL) is characterized by specific 15; 17), distinct morphologic picture, and clinical coagulopathy that contribute to the morbidity and mortality of the disease. This study aims to investigate the effects of antitelomerase compound BIBR1532 on APL cells (NB4). BIBR 1532 exerts a direct short-term growth suppressive effect in a concentration-dependent manner probably through downregulation of c-Myc and hTERT expression. Our results also suggest that induction of p21 and subsequent disturbance of Bax/Bcl-2 balanced ratio as well as decreased telomerase activity may be rational mechanisms for the potent/direct short-term cytotoxicity of high doses of BIBR1532 against NB4 cells.

引用

页码：57 / 64

页数：8

共 6 条

[1] SELECTIVE CYTOTOXICITY OF BIBR 1532 ON ACUTE PROMYELOCYTIC LEUKEMIA CELLS THROUGH INDUCTION OF P21 AND SUPPRESSION OF C-MYC-DEPENDENT TRANSCRIPTION OF HTERT
Bashash, D.
Kazerani, M.
Hezave, K.
Alimoghaddam, K.
Ghavamzadeh, A.
Ghaffari, S. H.
ANNALS OF ONCOLOGY, 2010, 21 : 358 - 359
[2] Downregulation of c-Myc and p21 expression and induction of S phase arrest by naphthalene diimide derivative in gastric adenocarcinoma cells
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Dana, Srikanta
Mandal, Kalyanashis
Mukhopadhyay, Pritam
Mondal, Neelima
CHEMICO-BIOLOGICAL INTERACTIONS, 2019, 304 : 106 - 123
[3] The growth arrest and downregulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequestering
Alesse, E
Zazzeroni, F
Angelucci, A
Giannini, G
Di Marcotullio, L
Gulino, A
CELL DEATH AND DIFFERENTIATION, 1998, 5 (05): : 381 - 389
[4] The growth arrest and downregulation of c-myc transcription induced by ceramide are related events dependent on p21 induction, Rb underphosphorylation and E2F sequestering
Edoardo Alesse
Francesca Zazzeroni
Adriano Angelucci
Giuseppe Giannini
Lucia Di Marcotullio
Alberto Gulino
Cell Death & Differentiation, 1998, 5 : 381 - 389
[5] Cytotoxic effect of arsenic trioxide on acute promyelocytic leukemia cells through suppression of NFkβ-dependent induction of hTERT due to down-regulation of Pin1 transcription
Ghaffari, Seyed H.
Momeny, Majid
Bashash, Davood
Mirzaei, Roohollah
Ghavamzadeh, Ardeshir
Alimoghaddam, Kamran
HEMATOLOGY, 2012, 17 (04) : 198 - 206
[6] Induced c-Myc regulates p21 transcription through proximal region of its promoter following increased polyamines in normal intestinal epithelial cells
Liu, Lan
Guo, Xin
Rao, Jaladanki N.
Zou, Tongtong
Marasa, Bernard S.
Chen, Jie
Greenspon, Jose
Casero, Robert A., Jr.
Wang, Jian-Ying
GASTROENTEROLOGY, 2006, 130 (04) : A540 - A540

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