Generation of an induced pluripotent stem cell line, FJMUUHi001-A, from a hereditary Parkinson's disease patient with homozygous mutation of c.189dupA in PARK7

被引：1
|
作者：
Chen, Zhi-Ting [1 ,2 ]
Zhao, Zhen-Hua [2 ,3 ]
Chen, Li-Na [1 ,2 ]
Fan, Fei [4 ]
Cai, Guo-En [1 ,2 ]
Weng, Hui-Dan [1 ,2 ]
Wang, Ying-Qing [1 ,2 ]
Liao, Lian-Ming [5 ]
Chen, Xiao-Chun [2 ]
Huang, En [6 ]
Ye, Qin-Yong [1 ,2 ]
机构：
[1] Fujian Med Univ, Fujian Inst Geriatr, Dept Neurol, Union Hosp, Fuzhou 350001, Peoples R China
[2] Fujian Med Univ, Inst Neurosci, Fujian Key Lab Mol Neurol, Fuzhou 350001, Peoples R China
[3] Fujian Med Univ, Shengli Clin Med Coll, Fuzhou 350001, Peoples R China
[4] Fujian Hlth Coll, Fuzhou 350101, Peoples R China
[5] Fujian Med Univ, Ctr Translat Med Hematol, Union Hosp, Fuzhou 350001, Peoples R China
[6] Fujian Med Univ, Sch Basic Med Sci, Fuzhou 350122, Peoples R China
来源：
STEM CELL RESEARCH | 2021年 / 51卷
基金：
中国国家自然科学基金;
关键词：
D O I：
10.1016/j.scr.2021.102175
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
PARK7 mutations are accountable for the inherited Parkinson's disease. An induced pluripotent stem cell (iPSC) line FJMUUHi001-A was generated by expressing five reprogramming factors, OCT3/4, SOX2, c-MYC, KLF4 and BCL-XL, in peripheral blood mononuclear cells from a 32-year old patient carrying a homozygous mutation of c.189dupA in PARK7. The iPSCs with a normal karyotype had the abilities to differentiate into three germ layers and expressed pluripotency markers without detectable residual plasmids. The cell line FJMUUHi001-A carrying the truncating protein PARK7 could be a useful tool to help comprehend the function of PARK7 in the iPSCs and differentiated cells from them.
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页数：4
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