ID4 regulates mammary gland development by suppressing p38MAPK activity

被引：34

作者：

Dong, Jie ^{[1
]}

Huang, Shixia ^{[2
,3
]}

Caikovski, Marian ^{[4
]}

Ji, Shaoquan ^{[5
]}

McGrath, Amanda ^{[1
]}

Custorio, Myra G. ^{[2
]}

Creighton, Chad J. ^{[2
]}

Maliakkal, Paul ^{[1
]}

Bogoslovskaia, Ekaterina ^{[1
]}

Du, Zhijun ^{[1
]}

Zhang, Xiaomei ^{[1
]}

Lewis, Michael T. ^{[1
,2
,3
]}

Sablitzky, Fred ^{[6
]}

Brisken, Cathrin ^{[4
]}

Li, Yi ^{[1
,2
,3
]}

机构：

[1] Baylor Coll Med, Lester & Sue Smith Breast Ctr, Houston, TX 77030 USA

[2] Baylor Coll Med, Dan L Duncan Canc Ctr, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

[4] EPFL, ISREC Swiss Inst Expt Canc Res, NCCR Mol Oncol, CH-1066 Epalinges, Switzerland

[5] BioLegend, San Diego, CA 92121 USA

[6] Univ Nottingham, Inst Genet, Nottingham NG7 2UH, England

来源：

DEVELOPMENT | 2011年 / 138卷 / 23期

基金：

美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

ID4; p38MAPK; (MAPK14; MAPK11); Mammary development; Breast cancer; Wnt; Mouse; ESTROGEN-RECEPTOR-ALPHA; LOOP-HELIX PROTEINS; DUCTAL MORPHOGENESIS; KINASE INHIBITOR; BREAST-CANCER; MICE LACKING; STEM-CELLS; EXPRESSION; DIFFERENTIATION; APOPTOSIS;

D O I：

10.1242/dev.069203

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The ID family of helix-loop-helix proteins regulates cell proliferation and differentiation in many different developmental pathways, but the functions of ID4 in mammary development are unknown. We report that mouse Id4 is expressed in cap cells, basal cells and in a subset of luminal epithelial cells, and that its targeted deletion impairs ductal expansion and branching morphogenesis as well as cell proliferation induced by estrogen and/or progesterone. We discover that p38MAPK is activated in Id4-null mammary cells. p38MAPK is also activated following siRNA-mediated Id4 knockdown in transformed mammary cells. This p38MAPK activation is required for the reduced proliferation and increased apoptosis in Id4-ablated mammary glands. Therefore, ID4 promotes mammary gland development by suppressing p38MAPK activity.

引用

页码：5247 / 5256

页数：10

共 42 条

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