New cannabidiol (CBD) derivatives: Synthesis, anti-inflammatory activity, and molecular docking

被引：8
|
作者：
Zi, Cheng-Ting [1 ]
Xie, Yin-Rong [1 ,2 ]
Niu, Yun [1 ,2 ]
Liu, Zhen-Hao [1 ,2 ]
Yang, Liu [3 ]
Xi, Yong -Kai [1 ]
Li, Zhen-Jie [4 ]
Zhang, Feng-Mei [4 ]
Xiang, Ze-Min [1 ,2 ]
Sheng, Jun [1 ,2 ]
机构：
[1] Yunnan Agr Univ, Coll Sci, Key Lab Puer Tea Sci, Minist Educ, Kunming 650201, Peoples R China
[2] Yunnan Agr Univ, Coll Food Sci & Technol, Kunming 650201, Peoples R China
[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Chi, Kunming 650201, Peoples R China
[4] R&D Ctr China Tobacco Yunnan Ind Co Ltd, Yunnan Key Lab Tobacco Chem, Kunming 650231, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2022年 / 51卷
关键词：
Cannabidiol(CBD); Synthesis; Anti-inflammatory activity; Molecular docking; Solubility; INFLAMMATION; THERAPY; ALPHA;
D O I：
10.1016/j.phytol.2022.08.004
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A series of new cannabidiol (CBD) derivatives were synthesized by employing hydrogenation reaction and click chemistry. Then, the cytotoxicity and anti-inflammatory activities of cannabinoid derivatives were determined. Compound 14 was found to have low cytotoxicity and high anti-inflammatory activity, and the anti-inflammatory mechanism of compound 14 was preliminarily explored, which inhibited the synthesis and release of the pro-inflammatory cytokine TNF-alpha. The experimental results were confirmed by docking analysis. The water solubility of compound 14 was determined. Based on the results, the structure-activity relationships (SARs) of the CBD derivatives were discussed for exploring novel anti-inflammatory drugs.
引用
收藏
页码：97 / 103
页数：7
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