Is combination therapy for carbapenem-resistant Klebsiella pneumoniae the new standard of care?

被引：11
|
作者：
Watkins, Richard R. [1 ,2 ]
Deresinski, Stan [3 ]
机构：
[1] Northeast Ohio Med Univ, Dept Internal Med, Rootstown, OH 44272 USA
[2] Akron Gen Med Ctr, Div Infect Dis, Akron, OH USA
[3] Stanford Univ, Dept Med, Div Infect Dis, Sch Med, Stanford, CA 94305 USA
来源：
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY | 2015年 / 13卷 / 04期
关键词：
carbapenem-resistant Klebsiella pneumoniae; combination antibiotic therapy; BLOOD-STREAM INFECTIONS; GRAM-NEGATIVE BACTERIA; MONOTHERAPY; MORTALITY;
D O I：
10.1586/14787210.2015.1018825
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Carbapenem-resistant Klebsiella pneumoniae causes serious nosocomial infections and therapeutic options are limited. There is increasing evidence suggesting that combination antibiotic therapy is more effective than monotherapy and leads to better outcomes. However, questions remain about which regimen is optimal and how to balance the potential benefits of combination therapy versus the risks and possible complications (e.g., toxicity, increased costs, Clostridium difficile infection). Well-designed randomized clinical trials are needed to clarify these issues.
引用
收藏
页码：405 / 407
页数：3
相关论文
共 50 条
  • [1] Emergence of a carbapenem-resistant Klebsiella pneumoniae
    MacKenzie, FM
    Forbes, KJ
    DoraiJohn, T
    Amyes, SGB
    Gould, IM
    LANCET, 1997, 350 (9080): : 783 - 783
  • [2] Combination Regimens for Treatment of Carbapenem-Resistant Klebsiella pneumoniae Bloodstream Infections
    Gomez-Simmonds, A.
    Nelson, B.
    Eiras, D. P.
    Loo, A.
    Jenkins, S. G.
    Whittier, S.
    Calfee, D. P.
    Satlin, M. J.
    Kubin, C. J.
    Furuya, E. Y.
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2016, 60 (06) : 3601 - 3607
  • [3] Evaluation of the combination treatments with intravenous fosfomycin for carbapenem-resistant Klebsiella pneumoniae
    Onal, Ugur
    Tuzemen, Nazmiye Ulku
    Kaya, Pinar Kucukdemirci
    Iscimen, Remzi
    Girgin, Nermin Kelebek
    Ozakin, Cuneyt
    Kahveci, Ferda Sohret
    Akalin, Halis
    REVISTA DA ASSOCIACAO MEDICA BRASILEIRA, 2023, 69 (11):
  • [4] Epidemiological study of carbapenem-resistant Klebsiella pneumoniae
    Lin, Di
    Chen, Jian
    Yang, Yan
    Cheng, Jun
    Sun, Changgui
    OPEN MEDICINE, 2018, 13 (01): : 460 - 466
  • [5] Regional differences in carbapenem-resistant Klebsiella pneumoniae
    Wyres, Kelly
    Holt, Kathryn
    LANCET INFECTIOUS DISEASES, 2022, 22 (03): : 309 - 310
  • [6] Reducing dissemination of carbapenem-resistant Klebsiella pneumoniae
    Bassetti, Matteo
    Giacobbe, Daniele Roberto
    ANNALS OF TRANSLATIONAL MEDICINE, 2019, 7
  • [7] Limiting and controlling carbapenem-resistant Klebsiella pneumoniae
    Saidel-Odes, Lisa
    Borer, Abraham
    INFECTION AND DRUG RESISTANCE, 2014, 7 : 9 - 14
  • [8] Emergence of carbapenem-resistant hypervirulent Klebsiella pneumoniae
    Yao, Hong
    Qin, Shangshang
    Chen, Sheng
    Shen, Jianzhong
    Du, Xiang-Dang
    LANCET INFECTIOUS DISEASES, 2018, 18 (01): : 25 - 25
  • [9] Risk Factors for Subsequential Carbapenem-Resistant Klebsiella pneumoniae Clinical Infection Among Rectal Carriers with Carbapenem-Resistant Klebsiella pneumoniae
    Chen, Xia
    Liu, Qingnuan
    Liu, Wen-en
    Yan, Qun
    INFECTION AND DRUG RESISTANCE, 2020, 13 : 1299 - 1305
  • [10] Tigecycline for carbapenem-resistant Klebsiella pneumoniae infections in the intensive care unit
    Vardakas, Konstantinos Z.
    Matthaiou, Dimitrios K.
    Falagas, Matthew E.
    Antypa, Elli
    Koteli, Asimoula
    Antoniadou, Eleni
    INFECTIOUS DISEASES, 2015, 47 (10) : 751 - 753
12345